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F-Box And WD Repeat Domain Containing Protein 5 (FBXW5)

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Fbw5; F-box and WD-40 domain-containing protein 5

F-Box And WD Repeat Domain Containing Protein 5 (FBXW5)
CCC J891
HGNC 13613
MGI 1354731
PubMed 24082123
RGD 1305661
UniProt Q969U6
Wiki FBXW5
FBXW5 encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination.
The protein encoded by this gene contains WD-40 domains, in addition to an F-box motif, so it belongs to the Fbw class. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene, however, they were found to be nonsense-mediated mRNA decay (NMD) candidates, hence not represented.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant F-Box And WD Repeat Domain Containing Protein 5 (FBXW5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to F-Box And WD Repeat Domain Containing Protein 5 (FBXW5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to F-Box And WD Repeat Domain Containing Protein 5 (FBXW5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for F-Box And WD Repeat Domain Containing Protein 5 (FBXW5) CLIA Kit Customized Service Offer
n/a ELISA Kit for F-Box And WD Repeat Domain Containing Protein 5 (FBXW5) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant F-Box And WD Repeat Domain Containing Protein 5 (FBXW5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to F-Box And WD Repeat Domain Containing Protein 5 (FBXW5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to F-Box And WD Repeat Domain Containing Protein 5 (FBXW5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for F-Box And WD Repeat Domain Containing Protein 5 (FBXW5) CLIA Kit Customized Service Offer
n/a ELISA Kit for F-Box And WD Repeat Domain Containing Protein 5 (FBXW5) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant F-Box And WD Repeat Domain Containing Protein 5 (FBXW5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to F-Box And WD Repeat Domain Containing Protein 5 (FBXW5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to F-Box And WD Repeat Domain Containing Protein 5 (FBXW5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for F-Box And WD Repeat Domain Containing Protein 5 (FBXW5) CLIA Kit Customized Service Offer
n/a ELISA Kit for F-Box And WD Repeat Domain Containing Protein 5 (FBXW5) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "DNA sequence and analysis of human chromosome 9." Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  5. "Large-scale cDNA transfection screening for genes related to cancer development and progression." Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
  6. "WD40 protein FBW5 promotes ubiquitination of tumor suppressor TSC2 by DDB1-CUL4-ROC1 ligase."Genes Dev. 22:866-871(2008) [PubMed] [Europe PMC] [Abstract]
  7. "An F-box protein, FBXW5, negatively regulates TAK1 MAP3K in the IL-1beta signaling pathway."Biochem. Biophys. Res. Commun. 381:412-417(2009) [PubMed] [Europe PMC] [Abstract]
  8. "The SCF-FBXW5 E3-ubiquitin ligase is regulated by PLK4 and targets HsSAS-6 to control centrosome duplication."Nat. Cell Biol. 13:1004-1009(2011) [PubMed] [Europe PMC] [Abstract]