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WD Repeat Containing Domain Protein 5 (WDR5)

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BIG-3; SWD3; Set1c WD40 Repeat Protein; BMP2-induced 3-kb gene protein

WD Repeat Containing Domain Protein 5 (WDR5)
CCC J885
HGNC 12757
MGI 2155884
PubMed 24051374
RGD 1305159
UniProt P61964
Wiki WDR5
WDR5 encodes a member of the WD repeat protein family. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 7 WD repeats. Alternatively spliced transcript variants encoding the same protein have been identified.The deduced 328-amino acid protein is composed primarily of 7 WD40 repeats in a beta-propeller structure. Northern blot analysis of several mouse tissues detected highest expression in testis. Wdr5 was also expressed in immortalized murine bone marrow stromal cells, osteoblasts, osteocytes, and growth plate chondrocytes, as well as in primary calvarial osteoblasts. Immunohistochemical analysis of embryonic mouse bone detected Wdr5 in osteoblasts of calvariae.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant WD Repeat Containing Domain Protein 5 (WDR5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to WD Repeat Containing Domain Protein 5 (WDR5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to WD Repeat Containing Domain Protein 5 (WDR5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for WD Repeat Containing Domain Protein 5 (WDR5) CLIA Kit Customized Service Offer
n/a ELISA Kit for WD Repeat Containing Domain Protein 5 (WDR5) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant WD Repeat Containing Domain Protein 5 (WDR5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to WD Repeat Containing Domain Protein 5 (WDR5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to WD Repeat Containing Domain Protein 5 (WDR5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for WD Repeat Containing Domain Protein 5 (WDR5) CLIA Kit Customized Service Offer
n/a ELISA Kit for WD Repeat Containing Domain Protein 5 (WDR5) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant WD Repeat Containing Domain Protein 5 (WDR5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to WD Repeat Containing Domain Protein 5 (WDR5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to WD Repeat Containing Domain Protein 5 (WDR5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for WD Repeat Containing Domain Protein 5 (WDR5) CLIA Kit Customized Service Offer
n/a ELISA Kit for WD Repeat Containing Domain Protein 5 (WDR5) ELISA Kit Customized Service Offer
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  10. "PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex."J. Biol. Chem. 282:20395-20406(2007) [PubMed] [Europe PMC] [Abstract]
  11. "Wdr82 is a C-terminal domain-binding protein that recruits the Setd1A Histone H3-Lys4 methyltransferase complex to transcription start sites of transcribed human genes."Mol. Cell. Biol. 28:609-618(2008) [PubMed] [Europe PMC] [Abstract]
  12. "CHD8 is an ATP-dependent chromatin remodeling factor that regulates beta-catenin target genes."Mol. Cell. Biol. 28:3894-3904(2008) [PubMed] [Europe PMC] [Abstract]
  13. "Molecular regulation of H3K4 trimethylation by Wdr82, a component of human Set1/COMPASS."Mol. Cell. Biol. 28:7337-7344(2008) [PubMed] [Europe PMC] [Abstract]
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  15. "On the mechanism of multiple lysine methylation by the human mixed lineage leukemia protein-1 (MLL1) core complex."J. Biol. Chem. 284:24242-24256(2009) [PubMed] [Europe PMC] [Abstract]
  16. "The double-histone-acetyltransferase complex ATAC is essential for mammalian development."Mol. Cell. Biol. 29:1176-1188(2009) [PubMed] [Europe PMC] [Abstract]
  17. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  18. "Subunit composition and substrate specificity of a MOF-containing histone acetyltransferase distinct from the male-specific lethal (MSL) complex."J. Biol. Chem. 285:4268-4272(2010) [PubMed] [Europe PMC] [Abstract]
  19. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  20. "Microcephaly gene links trithorax and REST/NRSF to control neural stem cell proliferation and differentiation."Cell 151:1097-1112(2012) [PubMed] [Europe PMC] [Abstract]
  21. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  22. "Structural basis for molecular recognition and presentation of histone H3 by WDR5."EMBO J. 25:4245-4252(2006) [PubMed] [Europe PMC] [Abstract]
  23. "Structural basis for the specific recognition of methylated histone H3 lysine 4 by the WD-40 protein WDR5."Mol. Cell 22:137-144(2006) [PubMed] [Europe PMC] [Abstract]
  24. "Molecular recognition of histone H3 by the WD40 protein WDR5."Nat. Struct. Mol. Biol. 13:698-703(2006) [PubMed] [Europe PMC] [Abstract]
  25. "Histone H3 recognition and presentation by the WDR5 module of the MLL1 complex."Nat. Struct. Mol. Biol. 13:704-712(2006) [PubMed] [Europe PMC] [Abstract]
  26. "Structure of WDR5 bound to mixed lineage leukemia protein-1 peptide."J. Biol. Chem. 283:32158-32161(2008) [PubMed] [Europe PMC] [Abstract]
  27. "WDR5 interacts with mixed lineage leukemia (MLL) protein via the histone H3-binding pocket."J. Biol. Chem. 283:35258-35264(2008) [PubMed] [Europe PMC] [Abstract]