Melan A (MLANA)
[Edit]MART1; Melanoma antigen recognized by T-cells 1; Antigen LB39-AA; Antigen SK29-AA
MART1 regulated the expression, stability, trafficking, and processing of Pmel17. MART1 colocalized and formed a complex with the P100 form of Pmel17 within early subcellular compartments in melanocytic cells.
MART1 siRNA reduced Pmel17 expression, abrogated the processing of Pmel17 in post-Golgi compartments, and interrupted trafficking of Pmel17 to early melanosomes.Sequence analysis predicted that the 118-amino acid MLANA protein contains no leader sequence but has a putative transmembrane hydrophobic stretch, which may bind HLA-A2, followed by 3 arg residues. Northern blot analysis revealed high expression in melanomas and lower expression in melanocytes. MLANA was expressed in retina but not in other normal tissues or B- and T-cell lines.
Organism species: Homo sapiens (Human)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Melan A (MLANA) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to Melan A (MLANA) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Melan A (MLANA) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Melan A (MLANA) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Melan A (MLANA) | ELISA Kit Customized Service Offer |
Organism species: Mus musculus (Mouse)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Melan A (MLANA) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to Melan A (MLANA) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Melan A (MLANA) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Melan A (MLANA) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Melan A (MLANA) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Melan A (MLANA) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to Melan A (MLANA) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Melan A (MLANA) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Melan A (MLANA) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Melan A (MLANA) | ELISA Kit Customized Service Offer |
- "Cloning of the gene coding for a shared human melanoma antigen recognized by autologous T cells infiltrating into tumor."Proc. Natl. Acad. Sci. U.S.A. 91:3515-3519(1994) [PubMed] [Europe PMC] [Abstract]
- "A new gene coding for a differentiation antigen recognized by autologous cytolytic T lymphocytes on HLA-A2 melanomas."J. Exp. Med. 180:35-42(1994) [PubMed] [Europe PMC] [Abstract]
- "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
- "DNA sequence and analysis of human chromosome 9." Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "Subcellular localization of the melanoma-associated protein Melan-AMART-1 influences the processing of its HLA-A2-restricted epitope."J. Biol. Chem. 276:43189-43196(2001) [PubMed] [Europe PMC] [Abstract]
- "The melanocytic protein Melan-A/MART-1 has a subcellular localization distinct from typical melanosomal proteins."Traffic 3:678-693(2002) [PubMed] [Europe PMC] [Abstract]
- "MART-1 is required for the function of the melanosomal matrix protein PMEL17/GP100 and the maturation of melanosomes."J. Biol. Chem. 280:14006-14016(2005) [PubMed] [Europe PMC] [Abstract]
- "The ocular albinism type 1 (OA1) G-protein-coupled receptor functions with MART-1 at early stages of melanogenesis to control melanosome identity and composition."Hum. Mol. Genet. 18:4530-4545(2009) [PubMed] [Europe PMC] [Abstract]
- "Structural basis for the presentation of tumor-associated MHC class II-restricted phosphopeptides to CD4+ T cells."J. Mol. Biol. 399:596-603(2010) [PubMed] [Europe PMC] [Abstract]