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Melan A (MLANA)

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MART1; Melanoma antigen recognized by T-cells 1; Antigen LB39-AA; Antigen SK29-AA

Melan A (MLANA)
CCC J880
HGNC 7124
MGI 108454
PubMed 10197235
RGD 1306525
UniProt Q16655
Wiki MLANA
MART1 regulated the expression, stability, trafficking, and processing of Pmel17. MART1 colocalized and formed a complex with the P100 form of Pmel17 within early subcellular compartments in melanocytic cells.
MART1 siRNA reduced Pmel17 expression, abrogated the processing of Pmel17 in post-Golgi compartments, and interrupted trafficking of Pmel17 to early melanosomes.Sequence analysis predicted that the 118-amino acid MLANA protein contains no leader sequence but has a putative transmembrane hydrophobic stretch, which may bind HLA-A2, followed by 3 arg residues. Northern blot analysis revealed high expression in melanomas and lower expression in melanocytes. MLANA was expressed in retina but not in other normal tissues or B- and T-cell lines.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Melan A (MLANA) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Melan A (MLANA) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Melan A (MLANA) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Melan A (MLANA) CLIA Kit Customized Service Offer
n/a ELISA Kit for Melan A (MLANA) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Melan A (MLANA) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Melan A (MLANA) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Melan A (MLANA) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Melan A (MLANA) CLIA Kit Customized Service Offer
n/a ELISA Kit for Melan A (MLANA) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Melan A (MLANA) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Melan A (MLANA) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Melan A (MLANA) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Melan A (MLANA) CLIA Kit Customized Service Offer
n/a ELISA Kit for Melan A (MLANA) ELISA Kit Customized Service Offer
  1. "Cloning of the gene coding for a shared human melanoma antigen recognized by autologous T cells infiltrating into tumor."Proc. Natl. Acad. Sci. U.S.A. 91:3515-3519(1994) [PubMed] [Europe PMC] [Abstract]
  2. "A new gene coding for a differentiation antigen recognized by autologous cytolytic T lymphocytes on HLA-A2 melanomas."J. Exp. Med. 180:35-42(1994) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "DNA sequence and analysis of human chromosome 9." Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Subcellular localization of the melanoma-associated protein Melan-AMART-1 influences the processing of its HLA-A2-restricted epitope."J. Biol. Chem. 276:43189-43196(2001) [PubMed] [Europe PMC] [Abstract]
  7. "The melanocytic protein Melan-A/MART-1 has a subcellular localization distinct from typical melanosomal proteins."Traffic 3:678-693(2002) [PubMed] [Europe PMC] [Abstract]
  8. "MART-1 is required for the function of the melanosomal matrix protein PMEL17/GP100 and the maturation of melanosomes."J. Biol. Chem. 280:14006-14016(2005) [PubMed] [Europe PMC] [Abstract]
  9. "The ocular albinism type 1 (OA1) G-protein-coupled receptor functions with MART-1 at early stages of melanogenesis to control melanosome identity and composition."Hum. Mol. Genet. 18:4530-4545(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Structural basis for the presentation of tumor-associated MHC class II-restricted phosphopeptides to CD4+ T cells."J. Mol. Biol. 399:596-603(2010) [PubMed] [Europe PMC] [Abstract]