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Polymerase DNA Directed Epsilon 2 (POLe2)

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DPE2; DNA polymerase II subunit 2; DNA polymerase epsilon subunit B

Polymerase DNA Directed Epsilon 2 (POLe2)
CCC J875
HGNC 9178
MGI 1197514
PubMed 9405441
RGD 1311962
UniProt P56282
Wiki POLE2
DNA polymerase epsilon (POLE) has been implicated in DNA repair and replication. Purified human HeLa POLE consists of a 261-kD catalytic subunit and a 55-kD accessory subunit. Li et al. (1997) cloned the small subunit of human POLE, which they symbolized DPE2. The cDNA predicted a 526-amino acid protein. The gene product has 26% identity to DPB2, a POLE accessory protein in the yeast S. cerevisiae.
Li et al. (1997) assigned the DPE2 gene to human chromosome 14 using human-rodent hybrid panels. The gene was then regionally localized to 14q13-q21 by fluorescence in situ hybridization.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Polymerase DNA Directed Epsilon 2 (POLe2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Polymerase DNA Directed Epsilon 2 (POLe2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Polymerase DNA Directed Epsilon 2 (POLe2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Polymerase DNA Directed Epsilon 2 (POLe2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Polymerase DNA Directed Epsilon 2 (POLe2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Polymerase DNA Directed Epsilon 2 (POLe2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Polymerase DNA Directed Epsilon 2 (POLe2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Polymerase DNA Directed Epsilon 2 (POLe2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Polymerase DNA Directed Epsilon 2 (POLe2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Polymerase DNA Directed Epsilon 2 (POLe2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Polymerase DNA Directed Epsilon 2 (POLe2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Polymerase DNA Directed Epsilon 2 (POLe2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Polymerase DNA Directed Epsilon 2 (POLe2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Polymerase DNA Directed Epsilon 2 (POLe2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Polymerase DNA Directed Epsilon 2 (POLe2) ELISA Kit Customized Service Offer
  1. "Purification, cDNA cloning, and gene mapping of the small subunit of human DNA polymerase epsilon."J. Biol. Chem. 272:32337-32344(1997) [PubMed] [Europe PMC] [Abstract]
  2. "The small subunits of human and mouse DNA polymerase epsilon are homologous to the second largest subunit of the yeast Saccharomyces cerevisiae DNA polymerase epsilon."Nucleic Acids Res. 26:730-734(1998) [PubMed] [Europe PMC] [Abstract]
  3. "E2F mediates induction of the Sp1-controlled promoter of the human DNA polymerase varepsilon B-subunit gene POLE2."Nucleic Acids Res. 29:2810-2821(2001) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence and analysis of human chromosome 14." Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Identification and cloning of two histone fold motif-containing subunits of HeLa DNA polymerase epsilon."J. Biol. Chem. 275:23247-23252(2000) [PubMed] [Europe PMC] [Abstract]