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Jumping Translocation Breakpoint Protein (JTB)

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PAR; B PAR; HJTB; hJT; Prostate Androgen-Regulated Gene

Jumping Translocation Breakpoint Protein (JTB)
CCC J873
HGNC 6201
MGI 1346082
PubMed 10321732
RGD 2942
UniProt O76095
Wiki JTB
The JTB open reading frame encodes a 146-amino acid protein with a 75-amino acid extracellular domain (after removal of the signal sequence), a 21-amino acid transmembrane domain, and a 20-amino acid intracellular domain.
The JTB protein is highly conserved among divergent eukaryotic species. Northern blot analysis showed ubiquitous expression of a 1-kb mRNA, with highest expression in thyroid and skeletal muscle. Kidney and spinal cord expressed an additional transcript of approximately 1.4 kb. The JTB gene contains 5 exons over a length of 3 kb. The jumping translocation resulted in a JTB truncation, which would potentially produce a JTB product devoid of the transmembrane domain. JTB is located in a gene-rich region at 1q21, called the epidermal differentiation complex (EDC).

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Jumping Translocation Breakpoint Protein (JTB) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Jumping Translocation Breakpoint Protein (JTB) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Jumping Translocation Breakpoint Protein (JTB) Polyclonal Antibody Customized Service Offer
Assay Kits SEJ873Hu ELISA Kit for Jumping Translocation Breakpoint Protein (JTB) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Jumping Translocation Breakpoint Protein (JTB) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Jumping Translocation Breakpoint Protein (JTB) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Jumping Translocation Breakpoint Protein (JTB) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Jumping Translocation Breakpoint Protein (JTB) CLIA Kit Customized Service Offer
n/a ELISA Kit for Jumping Translocation Breakpoint Protein (JTB) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Jumping Translocation Breakpoint Protein (JTB) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Jumping Translocation Breakpoint Protein (JTB) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Jumping Translocation Breakpoint Protein (JTB) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Jumping Translocation Breakpoint Protein (JTB) CLIA Kit Customized Service Offer
n/a ELISA Kit for Jumping Translocation Breakpoint Protein (JTB) ELISA Kit Customized Service Offer
  1. "JTB: a novel membrane protein gene at 1q21 rearranged in a jumping translocation."Oncogene 18:2085-2090(1999) [PubMed] [Europe PMC] [Abstract]
  2. "PAR, a novel androgen regulated gene, ubiquitously expressed in normal and malignant cells."Int. J. Oncol. 16:1055-1061(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells." Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Characterization of Jumping translocation breakpoint (JTB) gene product isolated as a TGF-beta1-inducible clone involved in regulation of mitochondrial function, cell growth and cell death."Oncogene 26:5991-6001(2007) [PubMed] [Europe PMC] [Abstract]
  8. "PAR, a protein involved in the cell cycle, is functionally related to chromosomal passenger proteins."Int. J. Oncol. 38:777-785(2011) [PubMed] [Europe PMC] [Abstract]
  9. "The structure of the extracellular domain of the jumping translocation breakpoint protein reveals a variation of the midkine fold."J. Mol. Biol. 415:22-28(2012) [PubMed] [Europe PMC] [Abstract]