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AF4/FMR2 Family, Member 1 (AFF1)

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AF-4; AF4; AF4-MLL; MLL/AF4; MLLT2; PBM1; Myeloid/Lymphoid Or Mixed-Lineage Leukemia; Translocated To 2; Pre-B-Cell Monocytic Leukemia Partner 1

AF4/FMR2 Family, Member 1 (AFF1)
CCC J872
HGNC 7135
MGI 1100819
PubMed 24367103
RGD 1307940
UniProt P51825
Wiki AFF1
The sequence of the complete open reading frame for this fusion transcript revealed that the MLL protein is homologous with DNA methyltransferase, the Drosophila trithorax gene product, and the 'AT-hook' motif of high mobility group proteins. An alternative splice that deletes the AT-hook region of MLL was identified. AF4 is a serine- and proline-rich putative transcription factor with a glutamine-rich carboxyl terminus.
The composition of the complete MLL-AF4 fusion product argues that it may act through either a gain-of-function or a dominant-negative mechanism in leukemogenesis. This gene is also symbolized MLLT2

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPJ872Hu01 Recombinant AF4/FMR2 Family, Member 1 (AFF1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAJ872Hu01 Polyclonal Antibody to AF4/FMR2 Family, Member 1 (AFF1) WB; IHC; ICC; IP.
MAJ872Hu21 Monoclonal Antibody to AF4/FMR2 Family, Member 1 (AFF1) WB; IHC; ICC; IP.
Assay Kits SEJ872Hu ELISA Kit for AF4/FMR2 Family, Member 1 (AFF1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant AF4/FMR2 Family, Member 1 (AFF1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to AF4/FMR2 Family, Member 1 (AFF1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to AF4/FMR2 Family, Member 1 (AFF1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for AF4/FMR2 Family, Member 1 (AFF1) CLIA Kit Customized Service Offer
n/a ELISA Kit for AF4/FMR2 Family, Member 1 (AFF1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant AF4/FMR2 Family, Member 1 (AFF1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to AF4/FMR2 Family, Member 1 (AFF1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to AF4/FMR2 Family, Member 1 (AFF1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for AF4/FMR2 Family, Member 1 (AFF1) CLIA Kit Customized Service Offer
n/a ELISA Kit for AF4/FMR2 Family, Member 1 (AFF1) ELISA Kit Customized Service Offer
  1. "Genes on chromosomes 4, 9, and 19 involved in 11q23 abnormalities in acute leukemia share sequence homology and/or common motifs."Proc. Natl. Acad. Sci. U.S.A. 90:4631-4635(1993) [PubMed] [Europe PMC] [Abstract]
  2. "A serine/proline-rich protein is fused to HRX in t(4;11) acute leukemias."Blood 81:1124-1131(1993) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  5. "The t(4;11) chromosome translocation of human acute leukemias fuses the ALL-1 gene, related to Drosophila trithorax, to the AF-4 gene."Cell 71:701-708(1992) [PubMed] [Europe PMC] [Abstract]
  6. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  7. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  12. "The little elongation complex regulates small nuclear RNA transcription."Mol. Cell 44:954-965(2011) [PubMed] [Europe PMC] [Abstract]
  13. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  14. "The super elongation complex (SEC) family in transcriptional control."Nat. Rev. Mol. Cell Biol. 13:543-547(2012) [PubMed] [Europe PMC] [Abstract]
  15. "Leukemia fusion target AF9 is an intrinsically disordered transcriptional regulator that recruits multiple partners via coupled folding and binding."Structure 21:176-183(2013) [PubMed] [Europe PMC] [Abstract]
  16. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]