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Hairy/Enhancer Of Split Related With YRPW Motif Protein 1 (HEY1)

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CHF2; HERP2; HESR1; HRT-1; OAF1; BHLHB31; Cardiovascular helix-loop-helix factor 2; Class B basic helix-loop-helix protein 31; Hairy-related transcription factor 1

Hairy/Enhancer Of Split Related With YRPW Motif Protein 1 (HEY1)
CCC J869
HGNC 4880
MGI 1341800
PubMed 15684393
RGD 621403
UniProt Q9Y5J3
Wiki HEY1
HEY1 encodes a nuclear protein belonging to the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcriptional repressors. Expression of this gene is induced by the Notch and c-Jun signal transduction pathways. Two similar and redundant genes in mouse are required for embryonic cardiovascular development, and are also implicated in neurogenesis and somitogenesis. The murine and human HEY1 proteins have 299 and 304 amino acids, respectively, and are identical in the 55-amino acid bHLH domain and in the last 13 amino acids of the C terminus, and 98% identical in the 44-amino acid 'orange' domain.mouse Hey1 is expressed at embryonic day 8 in the presomitic mesoderm and is widely expressed in tissues throughout gestation.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Hairy/Enhancer Of Split Related With YRPW Motif Protein 1 (HEY1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Hairy/Enhancer Of Split Related With YRPW Motif Protein 1 (HEY1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Hairy/Enhancer Of Split Related With YRPW Motif Protein 1 (HEY1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Hairy/Enhancer Of Split Related With YRPW Motif Protein 1 (HEY1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Hairy/Enhancer Of Split Related With YRPW Motif Protein 1 (HEY1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Hairy/Enhancer Of Split Related With YRPW Motif Protein 1 (HEY1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Hairy/Enhancer Of Split Related With YRPW Motif Protein 1 (HEY1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Hairy/Enhancer Of Split Related With YRPW Motif Protein 1 (HEY1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Hairy/Enhancer Of Split Related With YRPW Motif Protein 1 (HEY1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Hairy/Enhancer Of Split Related With YRPW Motif Protein 1 (HEY1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Hairy/Enhancer Of Split Related With YRPW Motif Protein 1 (HEY1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Hairy/Enhancer Of Split Related With YRPW Motif Protein 1 (HEY1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Hairy/Enhancer Of Split Related With YRPW Motif Protein 1 (HEY1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Hairy/Enhancer Of Split Related With YRPW Motif Protein 1 (HEY1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Hairy/Enhancer Of Split Related With YRPW Motif Protein 1 (HEY1) ELISA Kit Customized Service Offer
  1. "Identification and expression of a novel family of bHLH cDNAs related to Drosophila hairy and enhancer of split."Biochem. Biophys. Res. Commun. 260:459-465(1999) [PubMed] [Europe PMC] [Abstract]
  2. "Hey genes: a novel subfamily of hairy- and enhancer of split related genes specifically expressed during mouse embryogenesis."Mech. Dev. 85:173-177(1999) [PubMed] [Europe PMC] [Abstract]
  3. "Characterization of the human and mouse HEY1, HEY2, and HEYL genes: cloning, mapping, and mutation screening of a new bHLH gene family."Genomics 66:195-203(2000) [PubMed] [Europe PMC] [Abstract]
  4. "Cardiovascular basic helix loop helix factor 1, a novel transcriptional repressor expressed preferentially in the developing and adult cardiovascular system."J. Biol. Chem. 275:6381-6387(2000) [PubMed] [Europe PMC] [Abstract]
  5. "Members of the HRT family of basic helix-loop-helix proteins act as transcriptional repressors downstream of Notch signaling."Proc. Natl. Acad. Sci. U.S.A. 97:13655-13660(2000) [PubMed] [Europe PMC] [Abstract]
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  7. "DNA sequence and analysis of human chromosome 8." Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Hairy-related transcription factors inhibit GATA-dependent cardiac gene expression through a signal-responsive mechanism."J. Biol. Chem. 279:54937-54943(2004) [PubMed] [Europe PMC] [Abstract]
  10. "Crystal structure of hypothetical protein MS0332."Submitted (FEB-2009) to the PDB data bank