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Hairy/Enhancer Of Split Related With YRPW Motif Protein 2 (HEY2)

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BHLHB32; GRL; CHF1; HERP1; HESR2; HRT2; Cardiovascular helix-loop-helix factor 1; Class B basic helix-loop-helix protein 32; Hairy-related transcription factor 2; Protein gridlock

Hairy/Enhancer Of Split Related With YRPW Motif Protein 2 (HEY2)
CCC J868
HGNC 4881
MGI 1341884
PubMed 22408025
RGD 621405
UniProt Q9UBP5
Wiki HEY2
HEY2 encodes a member of the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcription factors. The encoded protein forms homo- or hetero-dimers that localize to the nucleus and interact with a histone deacetylase complex to repress transcription. Expression of this gene is induced by the Notch signal transduction pathway. Two similar and redundant genes in mouse are required for embryonic cardiovascular development, and are also implicated in neurogenesis and somitogenesis. Alternatively spliced transcript variants have been found, but their biological validity has not been determined.Hey2 is expressed in the mouse at embryonic day 8 in the presomitic mesoderm and is widely expressed in tissues throughout gestation.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Hairy/Enhancer Of Split Related With YRPW Motif Protein 2 (HEY2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Hairy/Enhancer Of Split Related With YRPW Motif Protein 2 (HEY2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Hairy/Enhancer Of Split Related With YRPW Motif Protein 2 (HEY2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Hairy/Enhancer Of Split Related With YRPW Motif Protein 2 (HEY2) CLIA Kit Customized Service Offer
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Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Hairy/Enhancer Of Split Related With YRPW Motif Protein 2 (HEY2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Hairy/Enhancer Of Split Related With YRPW Motif Protein 2 (HEY2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Hairy/Enhancer Of Split Related With YRPW Motif Protein 2 (HEY2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Hairy/Enhancer Of Split Related With YRPW Motif Protein 2 (HEY2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Hairy/Enhancer Of Split Related With YRPW Motif Protein 2 (HEY2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Hairy/Enhancer Of Split Related With YRPW Motif Protein 2 (HEY2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Hairy/Enhancer Of Split Related With YRPW Motif Protein 2 (HEY2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Hairy/Enhancer Of Split Related With YRPW Motif Protein 2 (HEY2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Hairy/Enhancer Of Split Related With YRPW Motif Protein 2 (HEY2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Hairy/Enhancer Of Split Related With YRPW Motif Protein 2 (HEY2) ELISA Kit Customized Service Offer
  1. "Hey genes: a novel subfamily of hairy- and enhancer of split related genes specifically expressed during mouse embryogenesis."Mech. Dev. 85:173-177(1999) [PubMed] [Europe PMC] [Abstract]
  2. "Gridlock, an HLH gene required for assembly of the aorta in zebrafish."Science 287:1820-1824(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Cardiovascular basic helix loop helix factor 1, a novel transcriptional repressor expressed preferentially in the developing and adult cardiovascular system."J. Biol. Chem. 275:6381-6387(2000) [PubMed] [Europe PMC] [Abstract]
  4. "Members of the HRT family of basic helix-loop-helix proteins act as transcriptional repressors downstream of Notch signaling."Proc. Natl. Acad. Sci. U.S.A. 97:13655-13660(2000) [PubMed] [Europe PMC] [Abstract]
  5. "HERP, a new primary target of Notch regulated by ligand binding."Mol. Cell. Biol. 21:6071-6079(2001) [PubMed] [Europe PMC] [Abstract]
  6. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Hairy-related transcription factors inhibit GATA-dependent cardiac gene expression through a signal-responsive mechanism."J. Biol. Chem. 279:54937-54943(2004) [PubMed] [Europe PMC] [Abstract]
  9. "CHF1/Hey2 suppresses SM-MHC promoter activity through an interaction with GATA-6."Biochem. Biophys. Res. Commun. 339:151-156(2006) [PubMed] [Europe PMC] [Abstract]
  10. "HEY2 mutations in malformed hearts."Hum. Mutat. 27:118-118(2006) [PubMed] [Europe PMC] [Abstract]