Achaete Scute Complex Like Protein 1 (ASCL1)
[Edit]ASH1; HASH1; MASH1; BHLHA46; Achaete Scute Homolog 1; Class A basic helix-loop-helix protein 46
Mash1 is expressed during development of rat retina and interacts specifically with an E-box identified in the promoter for the opsin gene during rod photoreceptor differentiation. It encodes a predicted protein of 238 amino acids that shares 95% identity with the mammalian achaete-scute homolog-1 (Mash1), a rodent basic helix-loop-helix factor.
The proximal coding region of the cDNA contains a striking 14-copy repeat of the triplet CAG that exhibits polymorphism in human genomic DNA; thus, ASCL1 is a candidate locus. Northern blot analysis revealed ASCL1 transcripts in RNA from a human MTC cell line, 2 fresh MTC tumors, fetal brain, and 3 lines of human SCLC. In contrast, cultured lines of non-SCLC lung cancers and a panel of normal adult human tissues showed no detectable ASCL1 transcripts.
Organism species: Homo sapiens (Human)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPJ867Hu01 | Recombinant Achaete Scute Complex Like Protein 1 (ASCL1) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | PAJ867Hu01 | Polyclonal Antibody to Achaete Scute Complex Like Protein 1 (ASCL1) | WB; IHC; ICC; IP. |
Assay Kits | SEJ867Hu | ELISA Kit for Achaete Scute Complex Like Protein 1 (ASCL1) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Mus musculus (Mouse)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Achaete Scute Complex Like Protein 1 (ASCL1) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to Achaete Scute Complex Like Protein 1 (ASCL1) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Achaete Scute Complex Like Protein 1 (ASCL1) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Achaete Scute Complex Like Protein 1 (ASCL1) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Achaete Scute Complex Like Protein 1 (ASCL1) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Achaete Scute Complex Like Protein 1 (ASCL1) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to Achaete Scute Complex Like Protein 1 (ASCL1) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Achaete Scute Complex Like Protein 1 (ASCL1) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Achaete Scute Complex Like Protein 1 (ASCL1) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Achaete Scute Complex Like Protein 1 (ASCL1) | ELISA Kit Customized Service Offer |
- "Identification of a human achaete-scute homolog highly expressed in neuroendocrine tumors."Proc. Natl. Acad. Sci. U.S.A. 90:5648-5652(1993) [PubMed] [Europe PMC] [Abstract]
- "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]