Achaete Scute Complex Like Protein 1 (ASCL1)

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ASH1; HASH1; MASH1; BHLHA46; Achaete Scute Homolog 1; Class A basic helix-loop-helix protein 46

Achaete Scute Complex Like Protein 1 (ASCL1)
Mash1 is expressed during development of rat retina and interacts specifically with an E-box identified in the promoter for the opsin gene during rod photoreceptor differentiation. It encodes a predicted protein of 238 amino acids that shares 95% identity with the mammalian achaete-scute homolog-1 (Mash1), a rodent basic helix-loop-helix factor.
The proximal coding region of the cDNA contains a striking 14-copy repeat of the triplet CAG that exhibits polymorphism in human genomic DNA; thus, ASCL1 is a candidate locus. Northern blot analysis revealed ASCL1 transcripts in RNA from a human MTC cell line, 2 fresh MTC tumors, fetal brain, and 3 lines of human SCLC. In contrast, cultured lines of non-SCLC lung cancers and a panel of normal adult human tissues showed no detectable ASCL1 transcripts.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPJ867Hu01 Recombinant Achaete Scute Complex Like Protein 1 (ASCL1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAJ867Hu01 Polyclonal Antibody to Achaete Scute Complex Like Protein 1 (ASCL1) WB; IHC; ICC; IP.
Assay Kits SEJ867Hu ELISA Kit for Achaete Scute Complex Like Protein 1 (ASCL1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Achaete Scute Complex Like Protein 1 (ASCL1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Achaete Scute Complex Like Protein 1 (ASCL1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Achaete Scute Complex Like Protein 1 (ASCL1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Achaete Scute Complex Like Protein 1 (ASCL1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Achaete Scute Complex Like Protein 1 (ASCL1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Achaete Scute Complex Like Protein 1 (ASCL1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Achaete Scute Complex Like Protein 1 (ASCL1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Achaete Scute Complex Like Protein 1 (ASCL1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Achaete Scute Complex Like Protein 1 (ASCL1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Achaete Scute Complex Like Protein 1 (ASCL1) ELISA Kit Customized Service Offer
  1. "Identification of a human achaete-scute homolog highly expressed in neuroendocrine tumors."Proc. Natl. Acad. Sci. U.S.A. 90:5648-5652(1993) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]