≡

Rho Guanine Nucleotide Exchange Factor 4 (ARHGEF4)

[Edit]

STM6; ASEF; APC-Stimulated Guanine Nucleotide Exchange Factor

Rho Guanine Nucleotide Exchange Factor 4 (ARHGEF4)
CCC J858
HGNC 684
MGI 2442507
PubMed 22543972
RGD 1586179
UniProt Q9NR80
Wiki ARHGEF4
Rho-like GTPases are activated by binding GTP and inactivated by conversion of GTP to GDP by their intrinsic GTPase activity. Guanine nucleotide exchange factors (GEFs), such as ARHGEF4, accelerate the GTPase activity of Rho GTPases by catalyzing their release of bound GDP.The full-length ASEF cDNA encodes a protein of 619 amino acids with motifs found in the Dbl (MCF2) family of proteins. ASEF contains Dbl homology (DH), pleckstrin (PLEK) homology (PH), and Src homology-3 (SH3) domains. Northern blot analysis revealed an Asef mRNA of 3.6 kb that was highly expressed in mouse brain. Immunohistochemical analysis revealed high Asef expression in mouse central nervous system, including hippocampus, olfactory bulb, and cerebellum, where Apc is also highly expressed.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Rho Guanine Nucleotide Exchange Factor 4 (ARHGEF4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Rho Guanine Nucleotide Exchange Factor 4 (ARHGEF4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Rho Guanine Nucleotide Exchange Factor 4 (ARHGEF4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Rho Guanine Nucleotide Exchange Factor 4 (ARHGEF4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Rho Guanine Nucleotide Exchange Factor 4 (ARHGEF4) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Rho Guanine Nucleotide Exchange Factor 4 (ARHGEF4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Rho Guanine Nucleotide Exchange Factor 4 (ARHGEF4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Rho Guanine Nucleotide Exchange Factor 4 (ARHGEF4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Rho Guanine Nucleotide Exchange Factor 4 (ARHGEF4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Rho Guanine Nucleotide Exchange Factor 4 (ARHGEF4) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Rho Guanine Nucleotide Exchange Factor 4 (ARHGEF4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Rho Guanine Nucleotide Exchange Factor 4 (ARHGEF4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Rho Guanine Nucleotide Exchange Factor 4 (ARHGEF4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Rho Guanine Nucleotide Exchange Factor 4 (ARHGEF4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Rho Guanine Nucleotide Exchange Factor 4 (ARHGEF4) ELISA Kit Customized Service Offer
  1. "Isolation of two novel human RhoGEFs, ARHGEF3 and ARHGEF4, in 3p13-21 and 2q22."Biochem. Biophys. Res. Commun. 273:364-369(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Asef, a link between the tumor suppressor APC and G-protein signaling."Science 289:1194-1197(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 6:197-205(1999) [PubMed] [Europe PMC] [Abstract]
  4. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
  5. "Mutated APC and Asef are involved in the migration of colorectal tumour cells."Nat. Cell Biol. 5:211-215(2003) [PubMed] [Europe PMC] [Abstract]
  6. "Asef2 functions as a Cdc42 exchange factor and is stimulated by the release of an autoinhibitory module from a concealed C-terminal activation element."Mol. Cell. Biol. 27:1380-1393(2007) [PubMed] [Europe PMC] [Abstract]
  7. "Identification and characterization of Asef2, a guanine-nucleotide exchange factor specific for Rac1 and Cdc42."Oncogene 26:7620-7627(2007) [PubMed] [Europe PMC] [Abstract]
  8. "The adenomatous polyposis coli-associated exchange factors Asef and Asef2 are required for adenoma formation in Apc(Min/+)mice."EMBO Rep. 10:1355-1362(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Crystal structure of the rac activator, Asef, reveals its autoinhibitory mechanism."J. Biol. Chem. 282:4238-4242(2007) [PubMed] [Europe PMC] [Abstract]
  10. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]