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Pallidin (PLDN)

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PA; BLOC1S6 ; BLOS6; HPS9; PA; PALLID; Pallid Homolog; Biogenesis of Lysosomal Organelles Complex-1, Subunit 6; Syntaxin 13-interacting protein

Pallidin (PLDN)
CCC J838
HGNC 8549
MGI 1927580
PubMed 11598191
RGD 1310208
UniProt Q9UL45
Wiki PLDN
Pallidin may play a role in intracellular vesicle trafficking. It interacts with Syntaxin 13 which mediates intracellular membrane fusion. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. 'Pallid' is 1 of 13 platelet storage pool deficiency (SPD) mouse mutants. Pallid (pa) animals suffer from prolonged bleeding time, pigment dilution, kidney lysosomal enzyme elevation, serum alpha-1-antitrypsin activity deficiency, and abnormal otolith formation. As with other mouse mutants of this class, characterization of pallid mice suggested a defect in organelle biosynthesis.The gene encodes a ubiquitously expressed, highly charged 172-amino acid protein, which they called pallidin, with no homology to known proteins.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Pallidin (PLDN) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Pallidin (PLDN) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Pallidin (PLDN) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Pallidin (PLDN) CLIA Kit Customized Service Offer
n/a ELISA Kit for Pallidin (PLDN) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Pallidin (PLDN) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Pallidin (PLDN) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Pallidin (PLDN) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Pallidin (PLDN) CLIA Kit Customized Service Offer
n/a ELISA Kit for Pallidin (PLDN) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Pallidin (PLDN) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Pallidin (PLDN) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Pallidin (PLDN) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Pallidin (PLDN) CLIA Kit Customized Service Offer
n/a ELISA Kit for Pallidin (PLDN) ELISA Kit Customized Service Offer
  1. "The pallid gene encodes a novel, syntaxin 13-interacting protein involved in platelet storage pool deficiency."Nat. Genet. 23:329-332(1999) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The pallidin (Pldn) gene and the role of SNARE proteins in melanosome biogenesis."Pigment Cell Res. 15:82-86(2002) [PubMed] [Europe PMC] [Abstract]
  5. "Pallidin is a component of a multi-protein complex involved in the biogenesis of lysosome-related organelles."Traffic 3:666-677(2002) [PubMed] [Europe PMC] [Abstract]
  6. "BLOC-1, a novel complex containing the pallidin and muted proteins involved in the biogenesis of melanosomes and platelet-dense granules."J. Biol. Chem. 277:28191-28199(2002) [PubMed] [Europe PMC] [Abstract]
  7. "BLOC-1 is required for cargo-specific sorting from vacuolar early endosomes toward lysosome-related organelles."Mol. Biol. Cell 18:768-780(2007) [PubMed] [Europe PMC] [Abstract]
  8. "The dysbindin-containing complex (BLOC-1) in brain: developmental regulation, interaction with SNARE proteins and role in neurite outgrowth."Mol. Psychiatry 15:204-215(2010) [PubMed] [Europe PMC] [Abstract]
  9. "A BLOC-1 mutation screen reveals that PLDN is mutated in Hermansky-Pudlak Syndrome type 9."Am. J. Hum. Genet. 88:778-787(2011) [PubMed] [Europe PMC] [Abstract]
  10. "The schizophrenia susceptibility factor dysbindin and its associated complex sort cargoes from cell bodies to the synapse."Mol. Biol. Cell 22:4854-4867(2011) [PubMed] [Europe PMC] [Abstract]
  11. "Assembly and architecture of biogenesis of lysosome-related organelles complex-1 (BLOC-1)."J. Biol. Chem. 287:5882-5890(2012) [PubMed] [Europe PMC] [Abstract]
  12. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]