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Phosphoinositide-3-Kinase Regulatory Subunit 2 (PIK3R2)

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P85B; p85-BETA; Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta

Phosphoinositide-3-Kinase Regulatory Subunit 2 (PIK3R2)
CCC J834
HGNC 8980
MGI 1098772
PubMed 22729224
RGD 68341
UniProt O00459
Wiki PIK3R2
Phosphatidylinositol 3-kinase (PI3K) is a lipid kinase that phosphorylates the inositol ring of phosphatidylinositol and related compounds at the 3-prime position. The products of these reactions serve as second messengers in growth signaling pathways. The kinase itself is made up of a catalytic subunit of molecular mass 110 kD (PIK3CA) and a regulatory subunit of either 85 kD, 55 kD, or 50 kD.
Both p85-alpha and p85-beta bound Xbp1s and increased its nuclear translocation, and it appeared that the p110 PI3K catalytic subunit and Xbp1s competed for binding of these regulatory subunits. p85-alpha and p85-beta formed an inactive dimer that was disrupted by insulin in a time-dependent manner, which promoted their association with Xbp1s.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Phosphoinositide-3-Kinase Regulatory Subunit 2 (PIK3R2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Phosphoinositide-3-Kinase Regulatory Subunit 2 (PIK3R2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Phosphoinositide-3-Kinase Regulatory Subunit 2 (PIK3R2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Phosphoinositide-3-Kinase Regulatory Subunit 2 (PIK3R2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phosphoinositide-3-Kinase Regulatory Subunit 2 (PIK3R2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Phosphoinositide-3-Kinase Regulatory Subunit 2 (PIK3R2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Phosphoinositide-3-Kinase Regulatory Subunit 2 (PIK3R2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Phosphoinositide-3-Kinase Regulatory Subunit 2 (PIK3R2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Phosphoinositide-3-Kinase Regulatory Subunit 2 (PIK3R2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phosphoinositide-3-Kinase Regulatory Subunit 2 (PIK3R2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Phosphoinositide-3-Kinase Regulatory Subunit 2 (PIK3R2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Phosphoinositide-3-Kinase Regulatory Subunit 2 (PIK3R2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Phosphoinositide-3-Kinase Regulatory Subunit 2 (PIK3R2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Phosphoinositide-3-Kinase Regulatory Subunit 2 (PIK3R2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phosphoinositide-3-Kinase Regulatory Subunit 2 (PIK3R2) ELISA Kit Customized Service Offer
  1. "Chromosomal localization of human p85 alpha, a subunit of phosphatidylinositol 3-kinase, and its homologue p85 beta."Oncogene 7:789-793(1992) [PubMed] [Europe PMC] [Abstract]
  2. "An oncogenic fusion product of the phosphatidylinositol 3-kinase p85beta subunit and HUMORF8, a putative deubiquitinating enzyme."Oncogene 16:1767-1772(1998) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and biology of human chromosome 19." Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Intracellular signaling of the Ufo/Axl receptor tyrosine kinase is mediated mainly by a multi-substrate docking-site."Oncogene 14:2619-2631(1997) [PubMed] [Europe PMC] [Abstract]
  6. "Tyrosine 1213 of Flt-1 is a major binding site of Nck and SHP-2."Biochem. Biophys. Res. Commun. 246:95-99(1998) [PubMed] [Europe PMC] [Abstract]
  7. "Activation of vascular endothelial growth factor receptor-3 and its downstream signaling promote cell survival under oxidative stress."J. Biol. Chem. 279:27088-27097(2004) [PubMed] [Europe PMC] [Abstract]
  8. "The tyrosine phosphatase CD148 interacts with the p85 regulatory subunit of phosphoinositide 3-kinase."Biochem. J. 413:193-200(2008) [PubMed] [Europe PMC] [Abstract]
  9. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  13. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  14. "FBXL2- and PTPL1-mediated degradation of p110-free p85beta regulatory subunit controls the PI(3)K signalling cascade."Nat. Cell Biol. 15:472-480(2013) [PubMed] [Europe PMC] [Abstract]
  15. "De novo germline and postzygotic mutations in AKT3, PIK3R2 and PIK3CA cause a spectrum of related megalencephaly syndromes." Nat. Genet. 44:934-940(2012) [PubMed] [Europe PMC] [Abstract]