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Phosphoinositide-3-Kinase Catalytic Delta Polypeptide (PIK3Cd)

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p110D; P110δ; Phosphoinositide-3-Kinase C; Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta

Phosphoinositide-3-Kinase Catalytic Delta Polypeptide (PIK3Cd)
CCC J832
HGNC 8977
MGI 1098211
PubMed 24293274
RGD 1310990
UniProt O00329
Wiki PIK3CD
Phosphoinositide 3-kinases (PI3Ks) phosphorylate the 3-prime OH position of the inositol ring of inositol lipids. The class I PI3Ks display a broad phosphoinositide lipid substrate specificity and include p110-alpha, p110-beta, and p110-gamma . p110-alpha and p110-beta interact with SH2/SH3-domain-containing p85 adaptor proteins and with GTP-bound Ras.
Like p110-alpha and p110-beta, p110-delta binds p85 adaptor proteins and GTP-bound Ras. These 3 class I PI3Ks were indistinguishable at the level of p85 adaptor protein selection or recruitment to activated receptor complexes. However, unlike p110-alpha, p110-delta does not phosphorylate p85, but instead has an autophosphorylation activity.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPJ832Hu01 Recombinant Phosphoinositide-3-Kinase Catalytic Delta Polypeptide (PIK3Cd) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAJ832Hu01 Polyclonal Antibody to Phosphoinositide-3-Kinase Catalytic Delta Polypeptide (PIK3Cd) WB; ICC; IHC-P; IHC-F; ELISA.
MAJ832Hu21 Monoclonal Antibody to Phosphoinositide-3-Kinase Catalytic Delta Polypeptide (PIK3Cd) WB; IHC; ICC; IP.
Assay Kits SEJ832Hu ELISA Kit for Phosphoinositide-3-Kinase Catalytic Delta Polypeptide (PIK3Cd) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Phosphoinositide-3-Kinase Catalytic Delta Polypeptide (PIK3Cd) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Phosphoinositide-3-Kinase Catalytic Delta Polypeptide (PIK3Cd) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Phosphoinositide-3-Kinase Catalytic Delta Polypeptide (PIK3Cd) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Phosphoinositide-3-Kinase Catalytic Delta Polypeptide (PIK3Cd) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phosphoinositide-3-Kinase Catalytic Delta Polypeptide (PIK3Cd) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Phosphoinositide-3-Kinase Catalytic Delta Polypeptide (PIK3Cd) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Phosphoinositide-3-Kinase Catalytic Delta Polypeptide (PIK3Cd) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Phosphoinositide-3-Kinase Catalytic Delta Polypeptide (PIK3Cd) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Phosphoinositide-3-Kinase Catalytic Delta Polypeptide (PIK3Cd) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phosphoinositide-3-Kinase Catalytic Delta Polypeptide (PIK3Cd) ELISA Kit Customized Service Offer
  1. "P110delta, a novel phosphoinositide 3-kinase in leukocytes."Proc. Natl. Acad. Sci. U.S.A. 94:4330-4335(1997) [PubMed] [Europe PMC] [Abstract]
  2. "p110delta, a novel phosphatidylinositol 3-kinase catalytic subunit that associates with p85 and is expressed predominantly in leukocytes."J. Biol. Chem. 272:19236-19241(1997) [PubMed] [Europe PMC] [Abstract]
  3. "p37delta is a new isoform of PI3K p110delta that increases cell proliferation and is overexpressed in tumors."Oncogene 31:3277-3286(2012) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Autophosphorylation of p110 delta phosphoinositide 3-kinase: a new paradigm for the regulation of lipid kinases in vitro and in vivo."EMBO J. 18:1292-1302(1999) [PubMed] [Europe PMC] [Abstract]
  7. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  8. "PI3K p110delta regulates T-cell cytokine production during primary and secondary immune responses in mice and humans."Blood 115:2203-2213(2010) [PubMed] [Europe PMC] [Abstract]
  9. "PI3K delta and PI3K gamma: partners in crime in inflammation in rheumatoid arthritis and beyond?"Nat. Rev. Immunol. 7:191-201(2007) [PubMed] [Europe PMC] [Abstract]
  10. "Phosphoinositide 3-kinase delta (PI3Kdelta) in leukocyte signaling and function."Cell. Signal. 23:603-608(2011) [PubMed] [Europe PMC] [Abstract]
  11. "Phosphoinositide 3-kinase delta gene mutation predisposes to respiratory infection and airway damage." Science 342:866-871(2013) [PubMed] [Europe PMC] [Abstract]