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Inhibitor Of Kappa Light Polypeptide Gene Enhancer In B-Cells Kinase Epsilon (IkBKe)

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IKK-i; IKKE; IKKI; Inducible I kappa-B kinase

Inhibitor Of Kappa Light Polypeptide Gene Enhancer In B-Cells Kinase Epsilon (IkBKe)
CCC J821
HGNC 14552
MGI 1929612
PubMed 23535865
RGD 1308352
UniProt Q14164
Wiki IKBKE
IKBKE is a noncanonical I-kappa-B kinase (IKK) that is essential for regulating antiviral signaling pathways. IKBKE has also been identified as a breast cancer oncogene and is amplified and overexpressed in over 30% of breast carcinomas and breast cancer cell lines .
Sequence analysis predicted that the 716-amino acid protein contains an N-terminal serine/threonine kinase domain and C-terminal leucine zipper and helix-loop-helix domains. Northern blot analysis revealed expression of a 4.0-kb transcript in spleen, thymus, peripheral blood leukocytes, pancreas, and placenta, with low expression in lung, kidney, prostate, ovary, and colon.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Inhibitor Of Kappa Light Polypeptide Gene Enhancer In B-Cells Kinase Epsilon (IkBKe) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Inhibitor Of Kappa Light Polypeptide Gene Enhancer In B-Cells Kinase Epsilon (IkBKe) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Inhibitor Of Kappa Light Polypeptide Gene Enhancer In B-Cells Kinase Epsilon (IkBKe) Polyclonal Antibody Customized Service Offer
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Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Inhibitor Of Kappa Light Polypeptide Gene Enhancer In B-Cells Kinase Epsilon (IkBKe) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Inhibitor Of Kappa Light Polypeptide Gene Enhancer In B-Cells Kinase Epsilon (IkBKe) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Inhibitor Of Kappa Light Polypeptide Gene Enhancer In B-Cells Kinase Epsilon (IkBKe) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Inhibitor Of Kappa Light Polypeptide Gene Enhancer In B-Cells Kinase Epsilon (IkBKe) CLIA Kit Customized Service Offer
n/a ELISA Kit for Inhibitor Of Kappa Light Polypeptide Gene Enhancer In B-Cells Kinase Epsilon (IkBKe) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Inhibitor Of Kappa Light Polypeptide Gene Enhancer In B-Cells Kinase Epsilon (IkBKe) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Inhibitor Of Kappa Light Polypeptide Gene Enhancer In B-Cells Kinase Epsilon (IkBKe) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Inhibitor Of Kappa Light Polypeptide Gene Enhancer In B-Cells Kinase Epsilon (IkBKe) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Inhibitor Of Kappa Light Polypeptide Gene Enhancer In B-Cells Kinase Epsilon (IkBKe) CLIA Kit Customized Service Offer
n/a ELISA Kit for Inhibitor Of Kappa Light Polypeptide Gene Enhancer In B-Cells Kinase Epsilon (IkBKe) ELISA Kit Customized Service Offer
  1. "IKK-i, a novel lipopolysaccharide-inducible kinase that is related to IkappaB kinases."Int. Immunol. 11:1357-1362(1999) [PubMed] [Europe PMC] [Abstract]
  2. "IKK epsilon is part of a novel PMA-inducible IkappaB kinase complex."Mol. Cell 5:513-522(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1."DNA Res. 2:167-174(1995) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Identification of NAP1, a regulatory subunit of IkappaB kinase-related kinases that potentiates NF-kappaB signaling."Mol. Cell. Biol. 23:7780-7793(2003) [PubMed] [Europe PMC] [Abstract]
  7. "Mechanisms of the TRIF-induced interferon-stimulated response element and NF-kappaB activation and apoptosis pathways."J. Biol. Chem. 279:15652-15661(2004) [PubMed] [Europe PMC] [Abstract]
  8. "SIKE is an IKK epsilon/TBK1-associated suppressor of TLR3- and virus-triggered IRF-3 activation pathways."EMBO J. 24:4018-4028(2005) [PubMed] [Europe PMC] [Abstract]
  9. "Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus."Nature 437:1167-1172(2005) [PubMed] [Europe PMC] [Abstract]
  10. "SINTBAD, a novel component of innate antiviral immunity, shares a TBK1-binding domain with NAP1 and TANK."EMBO J. 26:3180-3190(2007) [PubMed] [Europe PMC] [Abstract]
  11. "The DEAD-box helicase DDX3X is a critical component of the TANK-binding kinase 1-dependent innate immune response."EMBO J. 27:2135-2146(2008) [PubMed] [Europe PMC] [Abstract]
  12. "Viral targeting of DEAD box protein 3 reveals its role in TBK1/IKKepsilon-mediated IRF activation."EMBO J. 27:2147-2157(2008) [PubMed] [Europe PMC] [Abstract]
  13. "The tumour suppressor CYLD is a negative regulator of RIG-I-mediated antiviral response."EMBO Rep. 9:930-936(2008) [PubMed] [Europe PMC] [Abstract]
  14. "Ebola virus protein VP35 impairs the function of interferon regulatory factor-activating kinases IKKepsilon and TBK-1."J. Virol. 83:3069-3077(2009) [PubMed] [Europe PMC] [Abstract]
  15. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  16. "SUMOylation-dependent localization of IKKepsilon in PML nuclear bodies is essential for protection against DNA-damage-triggered cell death."Mol. Cell 37:503-515(2010) [PubMed] [Europe PMC] [Abstract]
  17. "Hepatitis B virus polymerase blocks pattern recognition receptor signaling via interaction with DDX3: implications for immune evasion."PLoS Pathog. 6:E1000986-E1000986(2010) [PubMed] [Europe PMC] [Abstract]
  18. "Novel cross-talk within the IKK family controls innate immunity."Biochem. J. 434:93-104(2011) [PubMed] [Europe PMC] [Abstract]
  19. "IkappaB kinase epsilon and TANK-binding kinase 1 activate AKT by direct phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 108:6474-6479(2011) [PubMed] [Europe PMC] [Abstract]
  20. "Arenavirus nucleoprotein targets interferon regulatory factor-activating kinase IKKepsilon."J. Virol. 86:7728-7738(2012) [PubMed] [Europe PMC] [Abstract]
  21. "IKKepsilon-mediated tumorigenesis requires K63-linked polyubiquitination by a cIAP1/cIAP2/TRAF2 E3 ubiquitin ligase complex."Cell Rep. 3:724-733(2013) [PubMed] [Europe PMC] [Abstract]
  22. "Human DEAD box helicase 3 couples IkappaB kinase epsilon to interferon regulatory factor 3 activation."Mol. Cell. Biol. 33:2004-2015(2013) [PubMed] [Europe PMC] [Abstract]
  23. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]