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Rho/Rac Guanine Nucleotide Exchange Factor 2 (ARHGEF2)

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P40; GEF; GEF-H1; GEFH1; LFP40; Guanine nucleotide exchange factor H1; Microtubule-regulated Rho-GEF; Proliferating cell nucleolar antigen p40

Rho/Rac Guanine Nucleotide Exchange Factor 2 (ARHGEF2)
CCC J812
HGNC 682
MGI 103264
PubMed 22949735
RGD 1304659
UniProt Q92974
Wiki ARHGEF2
Rho-related small GTPases are involved in regulating signal transduction cascades from extracellular stimuli to the cell nucleus and cytoskeleton. DBL-like guanine nucleotide exchange factors (GEFs), such as ARHGEF2, catalyze the exchange of bound GDP for GTP on Rho-related proteins.
The deduced protein contains 894 amino acids and has a calculated molecular mass of 100 kD. ARHGEF2 has an N-terminal zinc finger-like motif, followed by a DBL homology domain, a pleckstrin homology domain, and a C-terminal coiled-coil domain. Northern blot analysis detected a 4.4-kb transcript in all tissues tested, with highest expression in thymus, testis, and leukocytes.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Rho/Rac Guanine Nucleotide Exchange Factor 2 (ARHGEF2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Rho/Rac Guanine Nucleotide Exchange Factor 2 (ARHGEF2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Rho/Rac Guanine Nucleotide Exchange Factor 2 (ARHGEF2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Rho/Rac Guanine Nucleotide Exchange Factor 2 (ARHGEF2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Rho/Rac Guanine Nucleotide Exchange Factor 2 (ARHGEF2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Rho/Rac Guanine Nucleotide Exchange Factor 2 (ARHGEF2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Rho/Rac Guanine Nucleotide Exchange Factor 2 (ARHGEF2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Rho/Rac Guanine Nucleotide Exchange Factor 2 (ARHGEF2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Rho/Rac Guanine Nucleotide Exchange Factor 2 (ARHGEF2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Rho/Rac Guanine Nucleotide Exchange Factor 2 (ARHGEF2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Rho/Rac Guanine Nucleotide Exchange Factor 2 (ARHGEF2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Rho/Rac Guanine Nucleotide Exchange Factor 2 (ARHGEF2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Rho/Rac Guanine Nucleotide Exchange Factor 2 (ARHGEF2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Rho/Rac Guanine Nucleotide Exchange Factor 2 (ARHGEF2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Rho/Rac Guanine Nucleotide Exchange Factor 2 (ARHGEF2) ELISA Kit Customized Service Offer
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  21. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
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  23. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
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  25. "Control of NOD2 and Rip2-dependent innate immune activation by GEF-H1."Inflamm. Bowel Dis. 18:603-612(2012) [PubMed] [Europe PMC] [Abstract]
  26. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
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