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Testis Enhanced Gene Transcript (TEGT)

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BI-1; BAXI1; TMBIM6; Transmembrane BAX Inhibitor Motif Containing 6; BAX Inhibitor 1; Transmembrane BAX inhibitor motif-containing protein 6

Testis Enhanced Gene Transcript (TEGT)
CCC J810
HGNC 11723
MGI 99682
PubMed 8530040
RGD 3842
UniProt P55061
Wiki TEGT
TEGT in the rat and humans does not belong to any known gene family of vertebrates. The deduced amino acid sequence of the gene and a bacterial protein of unknown function show low but significant homology and very similar hydrophobicity profiles. The 2 different transcripts are due to alternative usage of 2 polyadenylation sites. The presence of a nuclear targeting motif indicates that the gene product must localize to the nucleus.
BI1 is an evolutionarily conserved integral membrane protein containing 6 predicted membrane-spanning segments and is predominantly localized to intracellular membranes, similar to BCL2 family proteins. The predicted protein contains 237 amino acids and is identical to TEGT.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Testis Enhanced Gene Transcript (TEGT) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Testis Enhanced Gene Transcript (TEGT) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Testis Enhanced Gene Transcript (TEGT) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Testis Enhanced Gene Transcript (TEGT) CLIA Kit Customized Service Offer
n/a ELISA Kit for Testis Enhanced Gene Transcript (TEGT) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Testis Enhanced Gene Transcript (TEGT) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Testis Enhanced Gene Transcript (TEGT) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Testis Enhanced Gene Transcript (TEGT) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Testis Enhanced Gene Transcript (TEGT) CLIA Kit Customized Service Offer
n/a ELISA Kit for Testis Enhanced Gene Transcript (TEGT) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Testis Enhanced Gene Transcript (TEGT) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Testis Enhanced Gene Transcript (TEGT) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Testis Enhanced Gene Transcript (TEGT) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Testis Enhanced Gene Transcript (TEGT) CLIA Kit Customized Service Offer
n/a ELISA Kit for Testis Enhanced Gene Transcript (TEGT) ELISA Kit Customized Service Offer
  1. "Identification of a novel conserved human gene, TEGT."Genomics 28:301-304(1995) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The finished DNA sequence of human chromosome 12." Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Bax inhibitor-1, a mammalian apoptosis suppressor identified by functional screening in yeast."Mol. Biol. Cell 1:337-346(1998) [PubMed] [Europe PMC] [Abstract]
  6. "Endoplasmic reticulum protein BI-1 modulates unfolded protein response signaling and protects against stroke and traumatic brain injury."Brain Res. 1370:227-237(2011) [PubMed] [Europe PMC] [Abstract]
  7. "The C terminus of Bax inhibitor-1 forms a Ca2+-permeable channel pore."J. Biol. Chem. 287:2544-2557(2012) [PubMed] [Europe PMC] [Abstract]
  8. "Six-transmembrane topology for Golgi anti-apoptotic protein (GAAP) and Bax inhibitor 1 (BI-1) provides model for the transmembrane Bax inhibitor-containing motif (TMBIM) family."J. Biol. Chem. 287:15896-15905(2012) [PubMed] [Europe PMC] [Abstract]