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Biogenesis Of Lysosomal Organelles Complex 1, Subunit 1 (BLOC1S1)

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BLOS1; GCN5L1; General Control Of Amino-Acid Synthesis 5-Like 1

Biogenesis Of Lysosomal Organelles Complex 1, Subunit 1 (BLOC1S1)
CCC J799
HGNC 4200
MGI 1195276
PubMed 22309213
RGD 1307564
UniProt P78537
Wiki BLOC1S1
BLOC1S1 is a component of the ubiquitously expressed BLOC1 multisubunit protein complex. BLOC1 is required for normal biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules.
The 545-bp cDNA, termed GCN5L1, encodes a 126-amino acid polypeptide having 23.5% identity to yeast GCN5. Northern blot analysis revealed transcription of this gene in all human tissues examined.The deduced BLOS1 protein contains coiled-coil regions and has a calculated molecular mass of 14.3 kD. Western blot analysis detected endogenous HeLa cell BLOS1 at an apparent molecular mass of 13 kD.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Biogenesis Of Lysosomal Organelles Complex 1, Subunit 1 (BLOC1S1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Biogenesis Of Lysosomal Organelles Complex 1, Subunit 1 (BLOC1S1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Biogenesis Of Lysosomal Organelles Complex 1, Subunit 1 (BLOC1S1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Biogenesis Of Lysosomal Organelles Complex 1, Subunit 1 (BLOC1S1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Biogenesis Of Lysosomal Organelles Complex 1, Subunit 1 (BLOC1S1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Biogenesis Of Lysosomal Organelles Complex 1, Subunit 1 (BLOC1S1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Biogenesis Of Lysosomal Organelles Complex 1, Subunit 1 (BLOC1S1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Biogenesis Of Lysosomal Organelles Complex 1, Subunit 1 (BLOC1S1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Biogenesis Of Lysosomal Organelles Complex 1, Subunit 1 (BLOC1S1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Biogenesis Of Lysosomal Organelles Complex 1, Subunit 1 (BLOC1S1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Biogenesis Of Lysosomal Organelles Complex 1, Subunit 1 (BLOC1S1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Biogenesis Of Lysosomal Organelles Complex 1, Subunit 1 (BLOC1S1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Biogenesis Of Lysosomal Organelles Complex 1, Subunit 1 (BLOC1S1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Biogenesis Of Lysosomal Organelles Complex 1, Subunit 1 (BLOC1S1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Biogenesis Of Lysosomal Organelles Complex 1, Subunit 1 (BLOC1S1) ELISA Kit Customized Service Offer
  1. "Molecular cloning of a novel human cDNA, RT14, containing a putative ORF highly conserved between human, fruit fly, and nematode."DNA Res. 2:235-237(1995) [PubMed] [Europe PMC] [Abstract]
  2. "The finished DNA sequence of human chromosome 12." Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Isolation and characterization of a human cDNA clone (GCN5L1) homologous to GCN5, a yeast transcription activator."Cytogenet. Cell Genet. 73:134-136(1996) [PubMed] [Europe PMC] [Abstract]
  5. "Identification of snapin and three novel proteins (BLOS1, BLOS2, and BLOS3/reduced pigmentation) as subunits of biogenesis of lysosome-related organelles complex-1 (BLOC-1)."J. Biol. Chem. 279:28393-28401(2004) [PubMed] [Europe PMC] [Abstract]
  6. "BLOC-1 is required for cargo-specific sorting from vacuolar early endosomes toward lysosome-related organelles."Mol. Biol. Cell 18:768-780(2007) [PubMed] [Europe PMC] [Abstract]
  7. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  8. "Identification of a molecular component of the mitochondrial acetyl transferase program; a novel role for GCN5L1."Biochem. J. 443:655-661(2012) [PubMed] [Europe PMC] [Abstract]
  9. "Assembly and architecture of biogenesis of lysosome-related organelles complex-1 (BLOC-1)."J. Biol. Chem. 287:5882-5890(2012) [PubMed] [Europe PMC] [Abstract]