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ELAV Like Protein 4 (ELAVL4)

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HUD; PNEM; Hu Antigen D; Embryonic Lethal,Abnormal Vision Like 4; Paraneoplastic encephalomyelitis antigen HuD

ELAV Like Protein 4 (ELAVL4)
CCC J777
HGNC 3315
MGI 107427
PubMed 18587682
RGD 1560027
UniProt P26378
Wiki ELAVL4
HuD is expressed only in neurons and it binds to AU-rich element-containing mRNAs. As a result of this interaction the half-life of the transcript is increased. HuD is important in neurons during brain development and plasticity.
ELAVL4 has specificity for 3-prime uridylate-rich untranslated regions of growth factor mRNAs. HUD binding to this region stabilized MYCN mRNA in cells. Ectopic overexpression of HUD in mouse fibroblasts dramatically inhibited decay of a reporter RNA fused to either full-length MYCN 3-prime UTR or to cis-acting destabilizing elements harboring HUD-binding sites.HUD may contribute to the malignant phenotype of neuroblastoma cells by stabilizing MYCN mRNA, thereby enhancing steady-state levels of expression of this oncogene.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant ELAV Like Protein 4 (ELAVL4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to ELAV Like Protein 4 (ELAVL4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to ELAV Like Protein 4 (ELAVL4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for ELAV Like Protein 4 (ELAVL4) CLIA Kit Customized Service Offer
n/a ELISA Kit for ELAV Like Protein 4 (ELAVL4) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant ELAV Like Protein 4 (ELAVL4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to ELAV Like Protein 4 (ELAVL4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to ELAV Like Protein 4 (ELAVL4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for ELAV Like Protein 4 (ELAVL4) CLIA Kit Customized Service Offer
n/a ELISA Kit for ELAV Like Protein 4 (ELAVL4) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant ELAV Like Protein 4 (ELAVL4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to ELAV Like Protein 4 (ELAVL4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to ELAV Like Protein 4 (ELAVL4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for ELAV Like Protein 4 (ELAVL4) CLIA Kit Customized Service Offer
n/a ELISA Kit for ELAV Like Protein 4 (ELAVL4) ELISA Kit Customized Service Offer
  1. "HuD, a paraneoplastic encephalomyelitis antigen, contains RNA-binding domains and is homologous to Elav and Sex-lethal."Cell 67:325-333(1991) [PubMed] [Europe PMC] [Abstract]
  2. "Novel products of the HuD, HuC, NNP-1 and alpha-internexin genes identified by autologous antibody screening of a pediatric neuroblastoma library."Int. J. Cancer 100:669-677(2002) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Paraneoplastic encephalomyelitis antigens bind to the AU-rich elements of mRNA."Neurology 45:544-550(1995) [PubMed] [Europe PMC] [Abstract]
  7. "RNA-binding analyses of HuC and HuD with the VEGF and c-myc 3'-untranslated regions using a novel ELISA-based assay."Nucleic Acids Res. 28:E20-E20(2000) [PubMed] [Europe PMC] [Abstract]
  8. "CARM1 regulates proliferation of PC12 cells by methylating HuD."Mol. Cell. Biol. 26:2273-2285(2006) [PubMed] [Europe PMC] [Abstract]
  9. "Structural basis for recognition of AU-rich element RNA by the HuD protein."Nat. Struct. Biol. 8:141-145(2001) [PubMed] [Europe PMC] [Abstract]