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Inhibitor of DNA Binding Protein 3 (ID3)

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HEIR-1; 1R21; BHLHB25; DNA-Binding Protein Inhibitor ID-3,Dominant Negative Helix-Loop-Helix Protein; Class B basic helix-loop-helix protein 25; Inhibitor of differentiation 3

Inhibitor of DNA Binding Protein 3 (ID3)
CCC J774
HGNC 5362
MGI 96398
PubMed 1628620
RGD 2860
UniProt Q02535
Wiki ID3
ID3 gene was localized to the neuroblastoma consensus deletion region, 1p36.2-p36.12. Its predicted protein was 95.8% identical to the mouse HLH462 protein and had clear homology to the mouse Id and Drosophila emc proteins. The gene was expressed at high abundance in adult lung, kidney, and adrenal medulla, but not in adult brain. Despite prominent HEIR1 expression in adrenal medulla, which is a prime target for neuroblastomas, 10 of 12 neuroblastoma-derived cell lines showed very low levels of HEIR1 mRNA. Low HEIR1 expression was generally found in tumor cell lines with NMYC overexpression, whereas the 2 cell lines displaying high HEIR1 levels did not overexpress NMYC.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Inhibitor of DNA Binding Protein 3 (ID3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Inhibitor of DNA Binding Protein 3 (ID3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Inhibitor of DNA Binding Protein 3 (ID3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Inhibitor of DNA Binding Protein 3 (ID3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Inhibitor of DNA Binding Protein 3 (ID3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Inhibitor of DNA Binding Protein 3 (ID3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Inhibitor of DNA Binding Protein 3 (ID3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Inhibitor of DNA Binding Protein 3 (ID3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Inhibitor of DNA Binding Protein 3 (ID3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Inhibitor of DNA Binding Protein 3 (ID3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Inhibitor of DNA Binding Protein 3 (ID3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Inhibitor of DNA Binding Protein 3 (ID3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Inhibitor of DNA Binding Protein 3 (ID3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Inhibitor of DNA Binding Protein 3 (ID3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Inhibitor of DNA Binding Protein 3 (ID3) ELISA Kit Customized Service Offer
  1. "Mutually exclusive expression of a helix-loop-helix gene and N-myc in human neuroblastomas and in normal development."EMBO J. 11:2563-2571(1992) [PubMed] [Europe PMC] [Abstract]
  2. "An immediate early human gene encodes an Id-like helix-loop-helix protein and is regulated by protein kinase C activation in diverse cell types."Oncogene 8:599-607(1993) [PubMed] [Europe PMC] [Abstract]
  3. "Structural organisation and chromosomal mapping of the human Id-3 gene."Gene 151:309-314(1994) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "The transcriptional repressor ID2 can interact with the canonical clock components CLOCK and BMAL1 and mediate inhibitory effects on mPer1 expression."J. Biol. Chem. 285:38987-39000(2010) [PubMed] [Europe PMC] [Abstract]
  8. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]