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IKAROS Family Zinc Finger Protein 1 (IKZF1)

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IK1; IKAROS; LYF1; ZNFN1A1; hIk-1; Lymphoid transcription factor LyF-1

IKAROS Family Zinc Finger Protein 1 (IKZF1)
CCC J768
HGNC 13176
MGI 1342540
PubMed 24366361
RGD 1562979
UniProt Q13422
Wiki IKZF1
The deduced human and mouse Ikaros proteins are 95% identical. Ikaros proteins are conserved in sequence composition and relative expression between human T cells and mouse thymocytes. The deduced 519-amino acid protein is 93% identical to the mouse Ikaros isoform 1/LyF1 isoform VI and contains 4 N-terminal and 2 C-terminal zinc finger domains. Ikaros is expressed in the hormone-producing pituitary corticomelanotroph cells of mice, where it binds the proopiomelanocortin promoter and regulates endogenous gene expression. Ikaros-null mice had contraction of the pituitary corticomelanotroph population, reduced circulating adrenocorticotrophic hormone levels, and adrenal glucocorticoid insufficiency.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant IKAROS Family Zinc Finger Protein 1 (IKZF1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to IKAROS Family Zinc Finger Protein 1 (IKZF1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to IKAROS Family Zinc Finger Protein 1 (IKZF1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for IKAROS Family Zinc Finger Protein 1 (IKZF1) CLIA Kit Customized Service Offer
n/a ELISA Kit for IKAROS Family Zinc Finger Protein 1 (IKZF1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant IKAROS Family Zinc Finger Protein 1 (IKZF1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to IKAROS Family Zinc Finger Protein 1 (IKZF1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to IKAROS Family Zinc Finger Protein 1 (IKZF1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for IKAROS Family Zinc Finger Protein 1 (IKZF1) CLIA Kit Customized Service Offer
n/a ELISA Kit for IKAROS Family Zinc Finger Protein 1 (IKZF1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant IKAROS Family Zinc Finger Protein 1 (IKZF1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to IKAROS Family Zinc Finger Protein 1 (IKZF1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to IKAROS Family Zinc Finger Protein 1 (IKZF1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for IKAROS Family Zinc Finger Protein 1 (IKZF1) CLIA Kit Customized Service Offer
n/a ELISA Kit for IKAROS Family Zinc Finger Protein 1 (IKZF1) ELISA Kit Customized Service Offer
  1. "Cloning and sequencing of hIk-1, a cDNA encoding a human homologue of mouse Ikaros/LyF-1."Immunol. Lett. 49:139-141(1996) [PubMed] [Europe PMC] [Abstract]
  2. "The Ikaros gene encodes a family of lymphocyte-restricted zinc finger DNA binding proteins, highly conserved in human and mouse."J. Immunol. 156:585-592(1996) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence of human chromosome 7." Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
  5. "Human chromosome 7: DNA sequence and biology." Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Ikaros DNA-binding proteins direct formation of chromatin remodeling complexes in lymphocytes."Immunity 10:345-355(1999) [PubMed] [Europe PMC] [Abstract]
  8. "The Ikaros gene, a central regulator of lymphoid differentiation, fuses to the BCL6 gene as a result of t(3;7)(q27;p12) translocation in a patient with diffuse large B-cell lymphoma."Blood 95:2719-2721(2000) [PubMed] [Europe PMC] [Abstract]
  9. "Eos and pegasus, two members of the Ikaros family of proteins with distinct DNA binding activities."J. Biol. Chem. 275:38347-38354(2000) [PubMed] [Europe PMC] [Abstract]
  10. "Human Ikaros function in activated T cells is regulated by coordinated expression of its largest isoforms."J. Biol. Chem. 282:2538-2547(2007) [PubMed] [Europe PMC] [Abstract]
  11. "The role of Ikaros in human erythroid differentiation."Blood 111:1138-1146(2008) [PubMed] [Europe PMC] [Abstract]
  12. "Human gamma-satellite DNA maintains open chromatin structure and protects a transgene from epigenetic silencing."Genome Res. 19:533-544(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Deletion of IKZF1 and prognosis in acute lymphoblastic leukemia." N. Engl. J. Med. 360:470-480(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  15. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  16. "Cell cycle-specific function of Ikaros in human leukemia."Pediatr. Blood Cancer 59:69-76(2012) [PubMed] [Europe PMC] [Abstract]
  17. "Serine phosphorylation by SYK is critical for nuclear localization and transcription factor function of Ikaros."Proc. Natl. Acad. Sci. U.S.A. 109:18072-18077(2012) [PubMed] [Europe PMC] [Abstract]
  18. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]