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Synovial Sarcoma, X Breakpoint 3 (SSX3)

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CT5.3; Cancer/testis antigen 5.3

Synovial Sarcoma, X Breakpoint 3 (SSX3)
CCC J763
HGNC 11337
PubMed 9378559
UniProt Q99909
By screening a testis cDNA library with a partial fragment of the SSX2 gene, de Leeuw et al. (1996) identified SSX3, a novel member of the Kruppel-associated box (KRAB)-containing SSX gene family. SSX3 encodes a deduced 188-amino acid protein that shares 90% sequence identity with SSX2.
The proximal Xp segment contains several low-copy repeats, suggesting that several duplication events occurred in this region.Unlike SSX1 and SSX2, SSX3 appears not to be involved in the chromosome translocation t(X;18)(p11.2;q11.2) commonly found in synovial sarcomas. Gure et al. (1997) independently cloned the SSX3 gene and showed that it is expressed in normal testis only. Analysis of 12 melanoma cell lines detected no expression of SSX3.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Synovial Sarcoma, X Breakpoint 3 (SSX3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Synovial Sarcoma, X Breakpoint 3 (SSX3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Synovial Sarcoma, X Breakpoint 3 (SSX3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Synovial Sarcoma, X Breakpoint 3 (SSX3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Synovial Sarcoma, X Breakpoint 3 (SSX3) ELISA Kit Customized Service Offer
  1. "A novel Kruppel-associated box containing the SSX gene (SSX3) on the human X chromosome is not implicated in t(X;18)-positive synovial sarcomas."Cytogenet. Cell Genet. 73:179-183(1996) [PubMed] [Europe PMC] [Abstract]
  2. "SSX: a multigene family with several members transcribed in normal testis and human cancer."Int. J. Cancer 72:965-971(1997) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence of the human X chromosome." Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The cancer-related protein SSX2 interacts with the human homologue of a Ras-like GTPase interactor, RAB3IP, and a novel nuclear protein, SSX2IP."Genes Chromosomes Cancer 34:285-298(2002) [PubMed] [Europe PMC] [Abstract]