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SET Nuclear Oncogene (SET)

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PHAPII; 2PP2A; IPP2A2; Protein Phosphatase Type 2A Inhibitor; Template-Activating Factor-I,Chromatin Remodelling Factor; Myeloid Leukemia-Associated SET Translocation

SET Nuclear Oncogene (SET)
CCC J757
HGNC 10760
MGI 1860267
PubMed 21515671
RGD 1307467
UniProt Q01105
Wiki Protein_SET
The SET gene encodes transcripts of 2.0 and 2.7 kb that result from the use of alternative polyadenylation sites. Both transcripts contained the open reading frame for a putative protein with a predicted molecular mass of 32 kD. The SET sequence showed homology with the yeast nucleosome assembly protein NAP-I. The only common sequence motif of SET and DEK proteins is an acidic region. SET has a long acidic tail, of which a large part is present in the predicted SET-CAN fusion protein.The mRNA encoding SET was expressed at much higher levels in transformed human and rodent cell lines than in cultured renal epithelial and primary endothelial cells. Consistent with a role for SET in cell proliferation, SET mRNA expression was markedly reduced in cells rendered quiescent by serum starvation, contact inhibition, or differentiation.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant SET Nuclear Oncogene (SET) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to SET Nuclear Oncogene (SET) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to SET Nuclear Oncogene (SET) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for SET Nuclear Oncogene (SET) CLIA Kit Customized Service Offer
n/a ELISA Kit for SET Nuclear Oncogene (SET) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant SET Nuclear Oncogene (SET) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to SET Nuclear Oncogene (SET) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to SET Nuclear Oncogene (SET) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for SET Nuclear Oncogene (SET) CLIA Kit Customized Service Offer
n/a ELISA Kit for SET Nuclear Oncogene (SET) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant SET Nuclear Oncogene (SET) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to SET Nuclear Oncogene (SET) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to SET Nuclear Oncogene (SET) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for SET Nuclear Oncogene (SET) CLIA Kit Customized Service Offer
n/a ELISA Kit for SET Nuclear Oncogene (SET) ELISA Kit Customized Service Offer
  1. "Can, a putative oncogene associated with myeloid leukemogenesis, may be activated by fusion of its 3' half to different genes: characterization of the set gene."Mol. Cell. Biol. 12:3346-3355(1992) [PubMed] [Europe PMC] [Abstract]
  2. "Purification and characterization of two putative HLA class II associated proteins: PHAPI and PHAPII."Biol. Chem. Hoppe-Seyler 375:113-126(1994) [PubMed] [Europe PMC] [Abstract]
  3. "Replication factor encoded by a putative oncogene, set, associated with myeloid leukemogenesis."Proc. Natl. Acad. Sci. U.S.A. 92:4279-4283(1995) [PubMed] [Europe PMC] [Abstract]
  4. "The myeloid leukemia-associated protein SET is a potent inhibitor of protein phosphatase 2A."J. Biol. Chem. 271:11059-11062(1996) [PubMed] [Europe PMC] [Abstract]
  5. "Inhibitors of protein phosphatase-2A from human brain structures, immunocytological localization and activities towards dephosphorylation of the Alzheimer type hyperphosphorylated tau."FEBS Lett. 579:363-372(2005) [PubMed] [Europe PMC] [Abstract]
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  7. "DNA sequence and analysis of human chromosome 9." Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Identification and characterization of SET, a nuclear phosphoprotein encoded by the translocation break point in acute undifferentiated leukemia."J. Biol. Chem. 269:2258-2262(1994) [PubMed] [Europe PMC] [Abstract]
  10. "Expression of SET, an inhibitor of protein phosphatase 2A, in renal development and Wilms' tumor."J. Am. Soc. Nephrol. 9:1873-1880(1998) [PubMed] [Europe PMC] [Abstract]
  11. "Regulation of histone acetylation and transcription by INHAT, a human cellular complex containing the Set oncoprotein."Cell 104:119-130(2001) [PubMed] [Europe PMC] [Abstract]
  12. "Identification and characterization of SEB, a novel protein that binds to the acute undifferentiated leukemia-associated protein SET."Eur. J. Biochem. 268:1340-1351(2001) [PubMed] [Europe PMC] [Abstract]
  13. "Granzyme A activates an endoplasmic reticulum-associated caspase-independent nuclease to induce single-stranded DNA nicks."J. Biol. Chem. 276:43285-43293(2001) [PubMed] [Europe PMC] [Abstract]
  14. "HMG2 interacts with the nucleosome assembly protein SET and is a target of the cytotoxic T-lymphocyte protease granzyme A."Mol. Cell. Biol. 22:2810-2820(2002) [PubMed] [Europe PMC] [Abstract]
  15. "Tumor suppressor NM23-H1 is a granzyme A-activated DNase during CTL-mediated apoptosis, and the nucleosome assembly protein SET is its inhibitor."Cell 112:659-672(2003) [PubMed] [Europe PMC] [Abstract]
  16. ErratumCell 115:241-241(2003)
  17. "Herpes simplex virus type 1 tegument protein VP22 interacts with TAF-I proteins and inhibits nucleosome assembly but not regulation of histone acetylation by INHAT."J. Gen. Virol. 84:2501-2510(2003) [PubMed] [Europe PMC] [Abstract]
  18. "Cleaving the oxidative repair protein Ape1 enhances cell death mediated by granzyme A."Nat. Immunol. 4:145-153(2003) [PubMed] [Europe PMC] [Abstract]
  19. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  20. "The exonuclease TREX1 is in the SET complex and acts in concert with NM23-H1 to degrade DNA during granzyme A-mediated cell death."Mol. Cell 23:133-142(2006) [PubMed] [Europe PMC] [Abstract]
  21. "Shugoshin collaborates with protein phosphatase 2A to protect cohesin."Nature 441:46-52(2006) [PubMed] [Europe PMC] [Abstract]
  22. "Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."J. Proteome Res. 6:4150-4162(2007) [PubMed] [Europe PMC] [Abstract]
  23. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  24. "FE65 binds Teashirt, inhibiting expression of the primate-specific caspase-4."PLoS ONE 4:E5071-E5071(2009) [PubMed] [Europe PMC] [Abstract]
  25. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  26. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  27. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  28. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  29. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  30. "Relationship between the structure of SET/TAF-Ibeta/INHAT and its histone chaperone activity."Proc. Natl. Acad. Sci. U.S.A. 104:4285-4290(2007) [PubMed] [Europe PMC] [Abstract]