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Tissue Specific Extinguisher 1 (TSE1)

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PRKAR1A; CAR; CNC; CNC1; PKR1; PRKAR1; Protein kinase,cAMP-Dependent,Regulatory,Type I,Alpha; cAMP-dependent protein kinase type I-alpha regulatory subunit

Tissue Specific Extinguisher 1 (TSE1)
CCC J751
HGNC 9388
MGI 104878
PubMed 22750141
RGD 3391
UniProt P10644
cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase A (PKA), which transduces the signal through phosphorylation of different target proteins. Four different regulatory subunits and three catalytic subunits of PKA have been identified in humans.
TSE1 is one of the regulatory subunits. This protein was found to be a tissue-specific extinguisher that down-regulates the expression of seven liver genes in hepatoma x fibroblast hybrids. Functional null mutations in this gene cause Carney complex (CNC), an autosomal dominant multiple neoplasia syndrome. This gene can fuse to the RET protooncogene by gene rearrangement and form the thyroid tumor-specific chimeric oncogene known as PTC2.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Tissue Specific Extinguisher 1 (TSE1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Tissue Specific Extinguisher 1 (TSE1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Tissue Specific Extinguisher 1 (TSE1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Tissue Specific Extinguisher 1 (TSE1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tissue Specific Extinguisher 1 (TSE1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Tissue Specific Extinguisher 1 (TSE1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Tissue Specific Extinguisher 1 (TSE1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Tissue Specific Extinguisher 1 (TSE1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Tissue Specific Extinguisher 1 (TSE1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tissue Specific Extinguisher 1 (TSE1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Tissue Specific Extinguisher 1 (TSE1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Tissue Specific Extinguisher 1 (TSE1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Tissue Specific Extinguisher 1 (TSE1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Tissue Specific Extinguisher 1 (TSE1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tissue Specific Extinguisher 1 (TSE1) ELISA Kit Customized Service Offer
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  3. "Subtractive hybridization cloning of a tissue-specific extinguisher: TSE1 encodes a regulatory subunit of protein kinase A."Cell 66:861-872(1991) [PubMed] [Europe PMC] [Abstract]
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  9. "The second subunit of the replication factor C complex (RFC40) and the regulatory subunit (RIalpha) of protein kinase A form a protein complex promoting cell survival."Cell Cycle 4:323-329(2005) [PubMed] [Europe PMC] [Abstract]
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  11. "Smad6 is a protein kinase X phosphorylation substrate and is required for HL-60 cell differentiation."Oncogene 25:4086-4098(2006) [PubMed] [Europe PMC] [Abstract]
  12. "PKA-mediated phosphorylation regulates the function of activation-induced deaminase (AID) in B cells."Proc. Natl. Acad. Sci. U.S.A. 103:395-400(2006) [PubMed] [Europe PMC] [Abstract]
  13. "Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment."J. Proteome Res. 7:5167-5176(2008) [PubMed] [Europe PMC] [Abstract]
  14. "Phosphoproteome of resting human platelets."J. Proteome Res. 7:526-534(2008) [PubMed] [Europe PMC] [Abstract]
  15. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  16. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  17. "Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography."Proteomics 8:1346-1361(2008) [PubMed] [Europe PMC] [Abstract]
  18. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  19. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  20. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  21. "Activity of retinoic acid receptor-alpha is directly regulated at its protein kinase A sites in response to follicle-stimulating hormone signaling."Endocrinology 151:2361-2372(2010) [PubMed] [Europe PMC] [Abstract]
  22. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  23. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  24. "Recurrent PRKAR1A mutation in acrodysostosis with hormone resistance."N. Engl. J. Med. 364:2218-2226(2011) [PubMed] [Europe PMC] [Abstract]
  25. "Control of PKA stability and signalling by the RING ligase praja2."Nat. Cell Biol. 13:412-422(2011) [PubMed] [Europe PMC] [Abstract]
  26. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  27. "An unusual presentation of Carney complex with diffuse primary pigmented nodular adrenocortical disease on one adrenal gland and a nonpigmented adrenocortical adenoma and focal primary pigmented nodular adrenocortical disease on the other."Endocr. J. 59:823-830(2012) [PubMed] [Europe PMC] [Abstract]
  28. "A small novel A-kinase anchoring protein (AKAP) that localizes specifically protein kinase A-regulatory subunit I (PKA-RI) to the plasma membrane."J. Biol. Chem. 287:43789-43797(2012) [PubMed] [Europe PMC] [Abstract]
  29. "Novel Mutation in PRKAR1A in Carney Complex."Korean J. Pathol. 46:595-600(2012) [PubMed] [Europe PMC] [Abstract]
  30. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
  31. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  32. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  33. "Comparative PRKAR1A genotype-phenotype analyses in humans with Carney complex and prkar1a haploinsufficient mice." Proc. Natl. Acad. Sci. U.S.A. 101:14222-14227(2004) [PubMed] [Europe PMC] [Abstract]
  34. "In vitro functional studies of naturally occurring pathogenic PRKAR1A mutations that are not subject to nonsense mRNA decay."Hum. Mutat. 29:633-639(2008) [PubMed] [Europe PMC] [Abstract]
  35. "Exome sequencing identifies PDE4D mutations as another cause of acrodysostosis."Am. J. Hum. Genet. 90:740-745(2012) [PubMed] [Europe PMC] [Abstract]
  36. "Exome sequencing identifies PDE4D mutations in acrodysostosis."Am. J. Hum. Genet. 90:746-751(2012) [PubMed] [Europe PMC] [Abstract]
  37. "PRKAR1A and PDE4D mutations cause acrodysostosis but two distinct syndromes with or without GPCR-signaling hormone resistance." J. Clin. Endocrinol. Metab. 97:E2328-E2338(2012) [PubMed] [Europe PMC] [Abstract]
  38. "PRKAR1A mutation affecting cAMP-mediated G protein-coupled receptor signaling in a patient with acrodysostosis and hormone resistance."J. Clin. Endocrinol. Metab. 97:E1808-E1813(2012) [PubMed] [Europe PMC] [Abstract]
  39. "Novel mutations of the PRKAR1A gene in patients with acrodysostosis."Clin. Genet. 84:531-538(2013) [PubMed] [Europe PMC] [Abstract]