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MutY Homolog (MUTYH)

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MYH; A/G-specific adenine DNA glycosylase

MutY Homolog (MUTYH)
CCC J746
HGNC 7527
MGI 1917853
PubMed 11092888
RGD 620045
UniProt Q9UIF7
Wiki MUTYH
MUTYH glycosylase, involved in oxidative DNA damage repair. The enzyme excises adenine bases from the DNA backbone at sites where adenine is inappropriately paired with guanine, cytosine, or 8-oxo-7,8-dihydroguanine, a major oxidatively damaged DNA lesion. The protein is localized to the nucleus and mitochondria. Mutations in this gene result in heritable predisposition to colon and stomach cancer. Multiple transcript variants encoding different isoforms have been found for this gene.
Mutations in the MUTYH gene cause an autosomal recessive form of familial adenomatous polyposis. Polyps caused by mutated MYH do not appear until adulthood and are less numerous than those found in patients with APC gene mutations.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPJ746Hu01 Recombinant MutY Homolog (MUTYH) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAJ746Hu01 Polyclonal Antibody to MutY Homolog (MUTYH) WB; IHC; ICC; IP.
MAJ746Hu21 Monoclonal Antibody to MutY Homolog (MUTYH) WB; IHC; ICC; IP.
Assay Kits SEJ746Hu ELISA Kit for MutY Homolog (MUTYH) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant MutY Homolog (MUTYH) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to MutY Homolog (MUTYH) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to MutY Homolog (MUTYH) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for MutY Homolog (MUTYH) CLIA Kit Customized Service Offer
n/a ELISA Kit for MutY Homolog (MUTYH) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant MutY Homolog (MUTYH) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to MutY Homolog (MUTYH) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to MutY Homolog (MUTYH) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for MutY Homolog (MUTYH) CLIA Kit Customized Service Offer
n/a ELISA Kit for MutY Homolog (MUTYH) ELISA Kit Customized Service Offer
  1. "Cloning and sequencing a human homolog (hMYH) of the Escherichia coli mutY gene whose function is required for the repair of oxidative DNA damage."J. Bacteriol. 178:3885-3892(1996) [PubMed] [Europe PMC] [Abstract]
  2. "Identification of human MutY homolog (hMYH) as a repair enzyme for 2-hydroxyadenine in DNA and detection of multiple forms of hMYH located in nuclei and mitochondria."Nucleic Acids Res. 28:1355-1364(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Identification of rare DNA variants in mitochondrial disorders with improved array-based sequencing."Nucleic Acids Res. 39:44-58(2011) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Solution structure of the NUDIX domain from human A/G-specific adenine DNA glycosylase alpha-3 splice isoform."Submitted (NOV-2005) to the PDB data bank
  7. "Inherited variants of MYH associated with somatic G:C-->T:A mutations in colorectal tumors."Nat. Genet. 30:227-232(2002) [PubMed] [Europe PMC] [Abstract]
  8. "Autosomal recessive colorectal adenomatous polyposis due to inherited mutations of MYH."Lancet 362:39-41(2003) [PubMed] [Europe PMC] [Abstract]
  9. "Multiple colorectal adenomas, classic adenomatous polyposis, and germ-line mutations in MYH."N. Engl. J. Med. 348:791-799(2003) [PubMed] [Europe PMC] [Abstract]
  10. "Germline MUTYH (MYH) mutations in Portuguese individuals with multiple colorectal adenomas."Hum. Mutat. 24:353-354(2004) [PubMed] [Europe PMC] [Abstract]
  11. "Genetic alterations of the MYH gene in gastric cancer."Oncogene 23:6820-6822(2004) [PubMed] [Europe PMC] [Abstract]
  12. "Heterogeneous molecular mechanisms underlie attenuated familial adenomatous polyposis."Genet. Med. 9:836-841(2007) [PubMed] [Europe PMC] [Abstract]
  13. "MUTYH mutations associated with familial adenomatous polyposis: functional characterization by a mammalian cell-based assay."Hum. Mutat. 31:159-166(2010) [PubMed] [Europe PMC] [Abstract]