Lipoma HMGIC Fusion Partner (LHFP)

LHFP is a member of the lipoma HMGIC fusion partner (LHFP) gene family, which is a subset of the superfamily of tetraspan transmembrane protein encoding genes. This gene is fused to a high-mobility group gene in a translocation-associated lipoma. Mutations in another LHFP-like gene result in deafness in humans and mice. Alternatively spliced transcript variants have been found; however, their full-length nature is not known.

LHFP gene is a fusion partner of HMGIC in a subgroup of lipomas with t(12;13). The expressed HMGIC/LHFP fusion transcript encodes the 3 DNA-binding domains of HMGIC followed by 69 amino acids encoded by frameshifted LHFP sequences.