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Alveolar Soft Part Sarcoma Chromosome Region, Candidate 1 (ASPSCR1)

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ASPCR1; ASPL; ASPS; RCC17; TUG; UBXD9; UBXN9; UBX Domain Protein 9; Renal papillary cell carcinoma protein 17; Alveolar soft part sarcoma locus

Alveolar Soft Part Sarcoma Chromosome Region, Candidate 1 (ASPSCR1)
CCC J720
HGNC 13825
MGI 1916188
PubMed 21835426
RGD 1588666
UniProt Q9BZE9
Wiki ASPSCR1
ASPSCR1 is fused with transcription factor TFE3 gene in ASPS and also in renal cell carcinomas. Several alternatively spliced transcript variants of this gene have been described, but their full length nature has not been determined. By amplification of the 5-prime portion of cDNAs containing the 3-prime portion of TFE3 in 2 ASPS cases, they identified a novel sequence, ASPSCR1 (designated ASPL by the authors), fused in-frame to TFE3 exon 4 or exon 3. RT-PCR analysis detected an ASPSCR1/TFE3 fusion transcript in all 12 ASPS cases studied. The ASPSCR1/TFE3 fusion replaces the N-terminal portion of TFE3 by the fused ASPSCR1 sequences, while retaining the TFE3 DNA-binding domain, implicating transcriptional deregulation in the pathogenesis of ASPS.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Alveolar Soft Part Sarcoma Chromosome Region, Candidate 1 (ASPSCR1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Alveolar Soft Part Sarcoma Chromosome Region, Candidate 1 (ASPSCR1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Alveolar Soft Part Sarcoma Chromosome Region, Candidate 1 (ASPSCR1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Alveolar Soft Part Sarcoma Chromosome Region, Candidate 1 (ASPSCR1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Alveolar Soft Part Sarcoma Chromosome Region, Candidate 1 (ASPSCR1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Alveolar Soft Part Sarcoma Chromosome Region, Candidate 1 (ASPSCR1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Alveolar Soft Part Sarcoma Chromosome Region, Candidate 1 (ASPSCR1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Alveolar Soft Part Sarcoma Chromosome Region, Candidate 1 (ASPSCR1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Alveolar Soft Part Sarcoma Chromosome Region, Candidate 1 (ASPSCR1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Alveolar Soft Part Sarcoma Chromosome Region, Candidate 1 (ASPSCR1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Alveolar Soft Part Sarcoma Chromosome Region, Candidate 1 (ASPSCR1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Alveolar Soft Part Sarcoma Chromosome Region, Candidate 1 (ASPSCR1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Alveolar Soft Part Sarcoma Chromosome Region, Candidate 1 (ASPSCR1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Alveolar Soft Part Sarcoma Chromosome Region, Candidate 1 (ASPSCR1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Alveolar Soft Part Sarcoma Chromosome Region, Candidate 1 (ASPSCR1) ELISA Kit Customized Service Offer
  1. "The der(17)t(X;17)(p11;q25) of human alveolar soft part sarcoma fuses the TFE3 transcription factor gene to ASPL, a novel gene at 17q25."Oncogene 20:48-57(2001) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Fusion of a novel gene, RCC17, to the TFE3 gene in t(X;17)(p11.2;q25.3)-bearing papillary renal cell carcinomas."Cancer Res. 61:4130-4135(2001) [PubMed] [Europe PMC] [Abstract]
  5. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  6. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  7. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  8. "The ubiquitin regulatory X (UBX) domain-containing protein TUG regulates the p97 ATPase and resides at the endoplasmic reticulum-golgi intermediate compartment."J. Biol. Chem. 287:6679-6692(2012) [PubMed] [Europe PMC] [Abstract]
  9. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
  10. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  11. "A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity."PLoS Genet. 9:E1003210-E1003210(2013) [PubMed] [Europe PMC] [Abstract]
  12. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]