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GLI Family Zinc Finger Protein 2 (GLI2)

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THP2, HPE9, THP1; Glioma-Associated Oncogene Family Zinc Finger 2; Tax-Responsive Element-2 Holding Protein; Tax Helper Protein 1

GLI Family Zinc Finger Protein 2 (GLI2)
CCC J715
HGNC 4318
MGI 95728
PubMed 9557682
RGD 1309270
UniProt P10070
Wiki GLI2
GLI2 encodes a protein which belongs to the C2H2-type zinc finger protein subclass of the Gli family. Members of this subclass are characterized as transcription factors which bind DNA through zinc finger motifs. These motifs contain conserved H-C links. Gli family zinc finger proteins are mediators of Sonic hedgehog (Shh) signaling and they are implicated as potent oncogenes in the embryonal carcinoma cell. The protein encoded by this gene localizes to the cytoplasm and activates patched Drosophila homolog (PTCH) gene expression. It is also thought to play a role during embryogenesis. The encoded protein is associated with several phenotypes- Greig cephalopolysyndactyly syndrome, Pallister-Hall syndrome, preaxial polydactyly type IV, postaxial polydactyly types A1 and B.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant GLI Family Zinc Finger Protein 2 (GLI2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to GLI Family Zinc Finger Protein 2 (GLI2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to GLI Family Zinc Finger Protein 2 (GLI2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for GLI Family Zinc Finger Protein 2 (GLI2) CLIA Kit Customized Service Offer
n/a ELISA Kit for GLI Family Zinc Finger Protein 2 (GLI2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant GLI Family Zinc Finger Protein 2 (GLI2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to GLI Family Zinc Finger Protein 2 (GLI2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to GLI Family Zinc Finger Protein 2 (GLI2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for GLI Family Zinc Finger Protein 2 (GLI2) CLIA Kit Customized Service Offer
n/a ELISA Kit for GLI Family Zinc Finger Protein 2 (GLI2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant GLI Family Zinc Finger Protein 2 (GLI2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to GLI Family Zinc Finger Protein 2 (GLI2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to GLI Family Zinc Finger Protein 2 (GLI2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for GLI Family Zinc Finger Protein 2 (GLI2) CLIA Kit Customized Service Offer
n/a ELISA Kit for GLI Family Zinc Finger Protein 2 (GLI2) ELISA Kit Customized Service Offer
  1. "Cloning of novel isoforms of the human Gli2 oncogene and their activities to enhance tax-dependent transcription of the human T-cell leukemia virus type 1 genome."J. Virol. 72:3958-3964(1998) [PubMed] [Europe PMC] [Abstract]
  2. "A previously unidentified amino-terminal domain regulates transcriptional activity of wild-type and disease-associated human GLI2."Hum. Mol. Genet. 14:2181-2188(2005) [PubMed] [Europe PMC] [Abstract]
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  4. "A new regulatory element that augments the Tax-dependent enhancer of human T-cell leukemia virus type 1 and cloning of cDNAs encoding its binding proteins."J. Virol. 67:5375-5382(1993) [PubMed] [Europe PMC] [Abstract]
  5. "The GLI-Kruppel family of human genes."Mol. Cell. Biol. 8:3104-3113(1988) [PubMed] [Europe PMC] [Abstract]
  6. "Loss-of-function mutations in the human GLI2 gene are associated with pituitary anomalies and holoprosencephaly-like features."Proc. Natl. Acad. Sci. U.S.A. 100:13424-13429(2003) [PubMed] [Europe PMC] [Abstract]
  7. "Application of active and kinase-deficient kinome collection for identification of kinases regulating hedgehog signaling."Cell 133:537-548(2008) [PubMed] [Europe PMC] [Abstract]
  8. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Identification of a novel serine/threonine kinase ULK3 as a positive regulator of Hedgehog pathway."Exp. Cell Res. 316:627-637(2010) [PubMed] [Europe PMC] [Abstract]
  10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  11. "Gli2 acetylation at lysine 757 regulates hedgehog-dependent transcriptional output by preventing its promoter occupancy."PLoS ONE 8:E65718-E65718(2013) [PubMed] [Europe PMC] [Abstract]
  12. "Novel heterozygous nonsense GLI2 mutations in patients with hypopituitarism and ectopic posterior pituitary lobe without holoprosencephaly."J. Clin. Endocrinol. Metab. 95:E384-E391(2010) [PubMed] [Europe PMC] [Abstract]
  13. "GLI2 mutations in four Brazilian patients: how wide is the phenotypic spectrum?"Am. J. Med. Genet. A 140:2571-2576(2006) [PubMed] [Europe PMC] [Abstract]