≡

Tribbles Homolog 3 (TRIB3)

[Edit]

TRB3; NIPK; SINK; SKIP3; C20orf97; p65-interacting inhibitor of NF-kappa-B; Neuronal cell death-inducible putative kinase

Tribbles Homolog 3 (TRIB3)
CCC J711
HGNC 16228
MGI 1345675
PubMed 22577090
RGD 708432
UniProt Q96RU7
Wiki TRIB3
TRIB3 is a putative protein kinase that is induced by the transcription factor NF-kappaB. The encoded protein is a negative regulator of NF-kappaB and can also sensitize cells to TNF- and TRAIL-induced apoptosis. In addition, this protein can negatively regulate the cell survival serine-threonine kinase AKT1.
Highest expression in liver, pancreas, peripheral blood leukocytes and bone marrow. Also highly expressed in a number of primary lung, colon and breast tumors. Expressed in spleen, thymus, and prostate and is undetectable in other examined tissues, including testis, ovary, small intestine, colon, leukocyte, heart, brain, placenta, lung, skeletal muscle, and kidney.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Tribbles Homolog 3 (TRIB3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Tribbles Homolog 3 (TRIB3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Tribbles Homolog 3 (TRIB3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Tribbles Homolog 3 (TRIB3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tribbles Homolog 3 (TRIB3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Tribbles Homolog 3 (TRIB3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Tribbles Homolog 3 (TRIB3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Tribbles Homolog 3 (TRIB3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Tribbles Homolog 3 (TRIB3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tribbles Homolog 3 (TRIB3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Tribbles Homolog 3 (TRIB3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Tribbles Homolog 3 (TRIB3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Tribbles Homolog 3 (TRIB3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Tribbles Homolog 3 (TRIB3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tribbles Homolog 3 (TRIB3) ELISA Kit Customized Service Offer
  1. "SKIP3, a novel Drosophila tribbles ortholog, is overexpressed in human tumors and is regulated by hypoxia."Oncogene 22:2823-2835(2003) [PubMed] [Europe PMC] [Abstract]
  2. "SINK is a p65-interacting negative regulator of NF-kappaB-dependent transcription."J. Biol. Chem. 278:27072-27079(2003) [PubMed] [Europe PMC] [Abstract]
  3. "Human tribbles, a protein family controlling mitogen-activated protein kinase cascades."J. Biol. Chem. 279:42703-42708(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Characterization of human NIPK (TRB3, SKIP3) gene activation in stressful conditions."Biochem. Biophys. Res. Commun. 330:210-218(2005) [PubMed] [Europe PMC] [Abstract]
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The DNA sequence and comparative analysis of human chromosome 20." Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "TRB3, a novel ER stress-inducible gene, is induced via ATF4-CHOP pathway and is involved in cell death."EMBO J. 24:1243-1255(2005) [PubMed] [Europe PMC] [Abstract]
  9. "TRB3 is a PI 3-kinase dependent indicator for nutrient starvation."Cell. Signal. 18:899-909(2006) [PubMed] [Europe PMC] [Abstract]
  10. "Critical and functional regulation of CHOP (C/EBP homologous protein) through the N-terminal portion."J. Biol. Chem. 282:35687-35694(2007) [PubMed] [Europe PMC] [Abstract]
  11. "Human Tribbles 3 protects nuclear DNA from cytidine deamination by APOBEC3A."J. Biol. Chem. 287:39182-39192(2012) [PubMed] [Europe PMC] [Abstract]
  12. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]