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H2A Histone Family, Member B (H2AFB)

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H2AFB3; H2AFB2; H2ABBD; H2A.Bbd; H2A Barr body-deficient; Histone H2A-Bbd type 2/3

H2A Histone Family, Member B (H2AFB)
CCC J706
HGNC 14455
MGI 3644875
PubMed 11080476
RGD 1561666
UniProt P0C5Z0
Wiki H2AFB3
The deduced 115-amino acid H2AFB protein has a calculated molecular mass of about 13 kD. It shares highest sequence identity with other H2A histones within the alpha helices of the histone fold, and it contains highly basic N and C termini. H2AFB is unique among H2A histones in that the protein does not possess conserved residues that are posttranslationally modified in other H2A histones, and the cDNA contains a polyadenylation sequence and poly(A) tail. Northern blot analysis detected a 0.9-kb transcript expressed only in testis. In 46,XY fibroblasts, fluorescence-tagged H2AFB localized to the nucleus. In female cells, it was excluded from Barr bodies.Double-labeling experiments showed colocalization of H2AFB and acetylated histone H4 in interphase nuclei and on metaphase chromosomes.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant H2A Histone Family, Member B (H2AFB) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to H2A Histone Family, Member B (H2AFB) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to H2A Histone Family, Member B (H2AFB) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for H2A Histone Family, Member B (H2AFB) CLIA Kit Customized Service Offer
n/a ELISA Kit for H2A Histone Family, Member B (H2AFB) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant H2A Histone Family, Member B (H2AFB) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to H2A Histone Family, Member B (H2AFB) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to H2A Histone Family, Member B (H2AFB) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for H2A Histone Family, Member B (H2AFB) CLIA Kit Customized Service Offer
n/a ELISA Kit for H2A Histone Family, Member B (H2AFB) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant H2A Histone Family, Member B (H2AFB) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to H2A Histone Family, Member B (H2AFB) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to H2A Histone Family, Member B (H2AFB) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for H2A Histone Family, Member B (H2AFB) CLIA Kit Customized Service Offer
n/a ELISA Kit for H2A Histone Family, Member B (H2AFB) ELISA Kit Customized Service Offer
  1. "A novel chromatin protein, distantly related to histone H2A, is largely excluded from the inactive X chromosome."J. Cell Biol. 152:375-384(2001) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence of the human X chromosome." Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Nucleosomes containing the histone variant H2A.Bbd organize only 118 base pairs of DNA."EMBO J. 23:3314-3324(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Assembly and disassembly of nucleosome core particles containing histone variants by human nucleosome assembly protein I."Mol. Cell. Biol. 25:10639-10651(2005) [PubMed] [Europe PMC] [Abstract]
  6. "Dissection of the unusual structural and functional properties of the variant H2A.Bbd nucleosome."EMBO J. 25:4234-4244(2006) [PubMed] [Europe PMC] [Abstract]
  7. "ATP-dependent chromatin remodeling is required for base excision repair in conventional but not in variant H2A.Bbd nucleosomes."Mol. Cell. Biol. 27:5949-5956(2007) [PubMed] [Europe PMC] [Abstract]
  8. "H2A.Bbd: a quickly evolving hypervariable mammalian histone that destabilizes nucleosomes in an acetylation-independent way."FASEB J. 22:316-326(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Quickly evolving histones, nucleosome stability and chromatin folding: all about histone H2A.Bbd."Gene 413:1-7(2008) [PubMed] [Europe PMC] [Abstract]
  10. "H2A.Bbd: an X-chromosome-encoded histone involved in mammalian spermiogenesis."Nucleic Acids Res. 38:1780-1789(2010) [PubMed] [Europe PMC] [Abstract]
  11. "Histone variant H2A.Bbd is associated with active transcription and mRNA processing in human cells."Mol. Cell 47:596-607(2012) [PubMed] [Europe PMC] [Abstract]