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Ajuba (JUB)

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LIM domain-containing protein ajuba

Ajuba (JUB)
CCC J702
HGNC 20250
MGI 1341886
PubMed 10330178
RGD 620407
UniProt Q96IF1
JUB proteins contribute to cell fate determination and regulate cell proliferation and differentiation. Plays an important role in regulation of the kinase activity of AURKA/Aurora-A for mitotic commitment.
The 5-prime UTR contains a GC-rich region, and the deduced protein contains 547 amino acids. The N-terminal two-thirds of the protein is rich in glycine and proline, and the C terminus contains 3 tandemly arrayed LIM domains most homologous to group-3 LIM proteins. Ajuba also has 2 stretches of proline-rich SH3 recognition motifs and a nuclear export signal. In adult mouse tissues, Ajuba was expressed in skin, brain, and genitourinary organs. Epitope-tagged Ajuba localized to the cytosol of transfected mouse fibroblasts, with trace amounts at the cell surface.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ajuba (JUB) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ajuba (JUB) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ajuba (JUB) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ajuba (JUB) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ajuba (JUB) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ajuba (JUB) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ajuba (JUB) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ajuba (JUB) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ajuba (JUB) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ajuba (JUB) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ajuba (JUB) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ajuba (JUB) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ajuba (JUB) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ajuba (JUB) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ajuba (JUB) ELISA Kit Customized Service Offer
  1. "Aurora-A and an interacting activator, the LIM protein Ajuba, are required for mitotic commitment in human cells."Cell 114:585-598(2003) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and analysis of human chromosome 14." Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The LIM protein Ajuba is recruited to cadherin-dependent cell junctions through an association with alpha-catenin."J. Biol. Chem. 278:1220-1228(2003) [PubMed] [Europe PMC] [Abstract]
  6. "The LIM protein Ajuba influences interleukin-1-induced NF-kappaB activation by affecting the assembly and activity of the protein kinase Czeta/p62/TRAF6 signaling complex."Mol. Cell. Biol. 25:4010-4022(2005) [PubMed] [Europe PMC] [Abstract]
  7. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  8. "LATS2-Ajuba complex regulates gamma-tubulin recruitment to centrosomes and spindle organization during mitosis."FEBS Lett. 580:782-788(2006) [PubMed] [Europe PMC] [Abstract]
  9. "The Ajuba LIM domain protein is a corepressor for SNAG domain mediated repression and participates in nucleocytoplasmic Shuttling."Cancer Res. 67:9097-9106(2007) [PubMed] [Europe PMC] [Abstract]
  10. "Ajuba LIM proteins are snail/slug corepressors required for neural crest development in Xenopus."Dev. Cell 14:424-436(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Ajuba functions as a histone deacetylase-dependent co-repressor for autoregulation of the growth factor-independent-1 transcription factor."J. Biol. Chem. 283:32056-32065(2008) [PubMed] [Europe PMC] [Abstract]
  12. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  13. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  14. "Ajuba LIM proteins are negative regulators of the Hippo signaling pathway."Curr. Biol. 20:657-662(2010) [PubMed] [Europe PMC] [Abstract]
  15. "LIM-domain proteins, LIMD1, Ajuba, and WTIP are required for microRNA-mediated gene silencing."Proc. Natl. Acad. Sci. U.S.A. 107:12499-12504(2010) [PubMed] [Europe PMC] [Abstract]
  16. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  17. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  18. "The LIMD1 protein bridges an association between the prolyl hydroxylases and VHL to repress HIF-1 activity."Nat. Cell Biol. 14:201-208(2012) [PubMed] [Europe PMC] [Abstract]
  19. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]