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Abl Interactor 1 (ABI1)

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ABI-1; E3B1; NAP1BP; SSH3BP1; Spectrin SH3 Domain Binding Protein 1; Abelson interactor 1; Abl-binding protein 4; Nap1-binding protein; Eps8 SH3 domain-binding protein

Abl Interactor 1 (ABI1)
CCC J696
HGNC 11320
MGI 104913
PubMed 22808230
RGD 621008
UniProt Q8IZP0
Wiki ABI1
ABI1 has been found to form a complex with EPS8 and SOS1, and is thought to be involved in the transduction of signals from Ras to Rac. In addition, the encoded protein may play a role in the regulation of EGF-induced Erk pathway activation as well as cytoskeletal reorganization and EGFR signaling.
Abi1 is adoptor protein. It interacts with c-Abl and WAVE2 which is actin polymerization regulator. It is known that Abi1 enhances the phosphorylation of WAVE2 by c-Abl. The phosphorylation of c-Abl promotes actin polymerization.Furthermore, Abi1 is component of WAVE complex. Some research paper showed that knock down of Abi1 by si(short interffering)RNA promoted degradation of WAVE complex proteins.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPJ696Hu01 Recombinant Abl Interactor 1 (ABI1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAJ696Hu01 Polyclonal Antibody to Abl Interactor 1 (ABI1) WB; IHC
MAJ696Hu21 Monoclonal Antibody to Abl Interactor 1 (ABI1) WB; IHC; ICC; IP.
Assay Kits SEJ696Hu ELISA Kit for Abl Interactor 1 (ABI1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Abl Interactor 1 (ABI1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Abl Interactor 1 (ABI1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Abl Interactor 1 (ABI1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Abl Interactor 1 (ABI1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Abl Interactor 1 (ABI1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Abl Interactor 1 (ABI1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Abl Interactor 1 (ABI1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Abl Interactor 1 (ABI1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Abl Interactor 1 (ABI1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Abl Interactor 1 (ABI1) ELISA Kit Customized Service Offer
  1. "Isolation and characterization of e3B1, an eps8 binding protein that regulates cell growth."Oncogene 14:233-241(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Identification of a candidate human spectrin Src homology 3 domain-binding protein suggests a general mechanism of association of tyrosine kinases with the spectrin-based membrane skeleton."J. Biol. Chem. 273:13681-13692(1998) [PubMed] [Europe PMC] [Abstract]
  3. "Isolation of hNap1BP which interacts with human Nap 1 (NCKAP1) whose expression is down-regulated in Alzheimer's disease."Gene 271:159-169(2001) [PubMed] [Europe PMC] [Abstract]
  4. "Induction of colonic epithelial cell apoptosis by p47-dependent oxidants(1)."FEBS Lett. 540:195-200(2003) [PubMed] [Europe PMC] [Abstract]
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The DNA sequence and comparative analysis of human chromosome 10." Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."Nat. Biotechnol. 21:566-569(2003) [PubMed] [Europe PMC] [Abstract]
  9. , Submitted (JUL-2007) to UniProtKB
  10. "Abl interactor 1 binds to sos and inhibits epidermal growth factor- and v-Abl-induced activation of extracellular signal-regulated kinases."Mol. Cell. Biol. 20:7591-7601(2000) [PubMed] [Europe PMC] [Abstract]
  11. "ABI-1, a human homolog to mouse Abl-interactor 1, fuses the MLL gene in acute myeloid leukemia with t(10;11)(p11.2;q23)."Blood 92:1125-1130(1998) [PubMed] [Europe PMC] [Abstract]
  12. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  13. "Allosteric inhibition of the nonMyristoylated c-Abl tyrosine kinase by phosphopeptides derived from Abi1/Hssh3bp1."Biochim. Biophys. Acta 1783:737-747(2008) [PubMed] [Europe PMC] [Abstract]
  14. "Phosphoproteome of resting human platelets."J. Proteome Res. 7:526-534(2008) [PubMed] [Europe PMC] [Abstract]
  15. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  16. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  17. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  18. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  19. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  20. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
  21. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  22. "HCMV pUL135 remodels the actin cytoskeleton to impair immune recognition of infected cells."Cell Host Microbe 16:201-214(2014) [PubMed] [Europe PMC] [Abstract]
  23. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]