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Alcohol Dehydrogenase, Iron Containing 1 (ADHFE1)

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HOT; Fe-containing alcohol dehydrogenase; Hydroxyacid-oxoacid transhydrogenase, mitochondrial

Alcohol Dehydrogenase, Iron Containing 1 (ADHFE1)
CCC J676
HGNC 16354
MGI 1923437
PubMed 17559793
RGD 1308863
UniProt Q8IWW8
The ADHFE1 gene encodes hydroxyacid-oxoacid transhydrogenase (EC 1.1.99.24), which is responsible for the oxidation of 4-hydroxybutyrate in mammalian tissues.
ADHFE1 encodes a deduced 467-amino acid protein with a predicted molecular mass of 50 kD. The protein shares 21 to 38% sequence identity with the type III ADHs of microbial organisms and 88%, 67%, and 53% identity with homologs in mouse, Drosophila, and C. elegans, respectively. Northern blot analysis detected a 2.4-kb transcript in liver only. MTC-panel screening PCR detected expression in adult liver, kidney, thymus, and spleen.Adhfe1 enzyme activity required both 4-hydroxybutyrate and alpha-ketoglutarate.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Alcohol Dehydrogenase, Iron Containing 1 (ADHFE1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Alcohol Dehydrogenase, Iron Containing 1 (ADHFE1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Alcohol Dehydrogenase, Iron Containing 1 (ADHFE1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Alcohol Dehydrogenase, Iron Containing 1 (ADHFE1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Alcohol Dehydrogenase, Iron Containing 1 (ADHFE1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Alcohol Dehydrogenase, Iron Containing 1 (ADHFE1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Alcohol Dehydrogenase, Iron Containing 1 (ADHFE1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Alcohol Dehydrogenase, Iron Containing 1 (ADHFE1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Alcohol Dehydrogenase, Iron Containing 1 (ADHFE1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Alcohol Dehydrogenase, Iron Containing 1 (ADHFE1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Alcohol Dehydrogenase, Iron Containing 1 (ADHFE1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Alcohol Dehydrogenase, Iron Containing 1 (ADHFE1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Alcohol Dehydrogenase, Iron Containing 1 (ADHFE1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Alcohol Dehydrogenase, Iron Containing 1 (ADHFE1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Alcohol Dehydrogenase, Iron Containing 1 (ADHFE1) ELISA Kit Customized Service Offer
  1. "Cloning and characterization of a novel human alcohol dehydrogenase gene (ADHFe1)."DNA Seq. 13:301-306(2002) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas."Oncogene 23:5901-5911(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Kinetic characterization of human hydroxyacid-oxoacid transhydrogenase: relevance to D-2-hydroxyglutaric and gamma-hydroxybutyric acidurias."J. Inherit. Metab. Dis. 28:921-930(2005) [PubMed] [Europe PMC] [Abstract]
  6. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  7. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]