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Activation Induced Cytidine Deaminase (AICDA)

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ARP2; AID; CDA2; HIGM2; Cytidine aminohydrolase; Single-stranded DNA cytosine deaminase

Activation Induced Cytidine Deaminase (AICDA)
CCC J659
HGNC 13203
MGI 1342279
PubMed 23181381
RGD 1303222
UniProt Q9GZX7
Wiki AICDA
AICDA encodes a RNA-editing deaminase that is a member of the cytidine deaminase family. The protein is involved in somatic hypermutation, gene conversion, and class-switch recombination of immunoglobulin genes. Defects in this gene are the cause of autosomal recessive hyper-IgM immunodeficiency syndrome type 2 (HIGM2).
Class switch recombination (CSR) is a region-specific DNA recombination reaction that replaces one immunoglobulin (Ig) heavy-chain constant region gene with another. This enables a single variable region gene to be used in conjunction with different downstream heavy-chain constant region genes, each having a unique biologic activity. AID, a putative RNA editing enzyme, is required for this action.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Activation Induced Cytidine Deaminase (AICDA) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Activation Induced Cytidine Deaminase (AICDA) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Activation Induced Cytidine Deaminase (AICDA) Polyclonal Antibody Customized Service Offer
Assay Kits SEJ659Hu ELISA Kit for Activation Induced Cytidine Deaminase (AICDA) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Activation Induced Cytidine Deaminase (AICDA) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Activation Induced Cytidine Deaminase (AICDA) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Activation Induced Cytidine Deaminase (AICDA) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Activation Induced Cytidine Deaminase (AICDA) CLIA Kit Customized Service Offer
n/a ELISA Kit for Activation Induced Cytidine Deaminase (AICDA) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Activation Induced Cytidine Deaminase (AICDA) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Activation Induced Cytidine Deaminase (AICDA) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Activation Induced Cytidine Deaminase (AICDA) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Activation Induced Cytidine Deaminase (AICDA) CLIA Kit Customized Service Offer
n/a ELISA Kit for Activation Induced Cytidine Deaminase (AICDA) ELISA Kit Customized Service Offer
  1. "Isolation, tissue distribution, and chromosomal localization of the human activation-induced cytidine deaminase (hAID) gene."Genomics 68:85-88(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2)." Cell 102:565-575(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Somatic hypermutation of the AID transgene in B and non-B cells."Proc. Natl. Acad. Sci. U.S.A. 99:12304-12308(2002) [PubMed] [Europe PMC] [Abstract]
  4. "The finished DNA sequence of human chromosome 12." Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Activation-induced cytidine deaminase shuttles between nucleus and cytoplasm like apolipoprotein B mRNA editing catalytic polypeptide 1."Proc. Natl. Acad. Sci. U.S.A. 101:1975-1980(2004) [PubMed] [Europe PMC] [Abstract]
  7. "PKA-mediated phosphorylation regulates the function of activation-induced deaminase (AID) in B cells."Proc. Natl. Acad. Sci. U.S.A. 103:395-400(2006) [PubMed] [Europe PMC] [Abstract]
  8. "Interaction between antibody-diversification enzyme AID and spliceosome-associated factor CTNNBL1."Mol. Cell 31:474-484(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain."Cell 145:423-434(2011) [PubMed] [Europe PMC] [Abstract]
  10. "CTNNBL1 is a novel nuclear localization sequence-binding protein that recognizes RNA-splicing factors CDC5L and Prp31."J. Biol. Chem. 286:17091-17102(2011) [PubMed] [Europe PMC] [Abstract]
  11. "Phosphorylation directly regulates the intrinsic DNA cytidine deaminase activity of activation-induced deaminase and APOBEC3G protein."J. Biol. Chem. 286:26568-26575(2011) [PubMed] [Europe PMC] [Abstract]
  12. "Histone chaperone Spt6 is required for class switch recombination but not somatic hypermutation."Proc. Natl. Acad. Sci. U.S.A. 108:7920-7925(2011) [PubMed] [Europe PMC] [Abstract]
  13. "BCL6 positively regulates AID and germinal center gene expression via repression of miR-155."J. Exp. Med. 209:2455-2465(2012) [PubMed] [Europe PMC] [Abstract]
  14. "Solubility-based genetic screen identifies RING finger protein 126 as an E3 ligase for activation-induced cytidine deaminase."Proc. Natl. Acad. Sci. U.S.A. 110:1029-1034(2013) [PubMed] [Europe PMC] [Abstract]
  15. "Association between a new polymorphism in the activation-induced cytidine deaminase gene and atopic asthma and the regulation of total serum IgE levels."J. Allergy Clin. Immunol. 108:382-386(2001) [PubMed] [Europe PMC] [Abstract]