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Aldo Keto Reductase Family 1, Member C1 (AKR1C1)

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DDH1; MBAB; DD1; HAKRC; BABP; HAKRD; HBAB; MCDR2; Dihydrodiol Dehydrogenase 1; 20-Alpha Hydroxysteroid Dehydrogenase; High-affinity hepatic bile acid-binding protein

Aldo Keto Reductase Family 1, Member C1 (AKR1C1)
CCC J655
HGNC 384
MGI 1933427
PubMed 21215737
RGD 1306847
UniProt Q04828
Wiki AKR1C1
AKR1C1 encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reduction of progesterone to the inactive form 20-alpha-hydroxy-progesterone. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14
Expressed in all tissues tested including liver, prostate, testis, adrenal gland, brain, uterus, mammary gland and keratinocytes. Highest levels found in liver, mammary gland and brain.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Aldo Keto Reductase Family 1, Member C1 (AKR1C1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Aldo Keto Reductase Family 1, Member C1 (AKR1C1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Aldo Keto Reductase Family 1, Member C1 (AKR1C1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Aldo Keto Reductase Family 1, Member C1 (AKR1C1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Aldo Keto Reductase Family 1, Member C1 (AKR1C1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Aldo Keto Reductase Family 1, Member C1 (AKR1C1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Aldo Keto Reductase Family 1, Member C1 (AKR1C1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Aldo Keto Reductase Family 1, Member C1 (AKR1C1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Aldo Keto Reductase Family 1, Member C1 (AKR1C1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Aldo Keto Reductase Family 1, Member C1 (AKR1C1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Aldo Keto Reductase Family 1, Member C1 (AKR1C1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Aldo Keto Reductase Family 1, Member C1 (AKR1C1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Aldo Keto Reductase Family 1, Member C1 (AKR1C1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Aldo Keto Reductase Family 1, Member C1 (AKR1C1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Aldo Keto Reductase Family 1, Member C1 (AKR1C1) ELISA Kit Customized Service Offer
  1. "cDNA cloning and expression of the human hepatic bile acid-binding protein. A member of the monomeric reductase gene family."J. Biol. Chem. 268:10448-10457(1993) [PubMed] [Europe PMC] [Abstract]
  2. "Genomic organization and chromosomal localization of a novel human hepatic dihydrodiol dehydrogenase with high affinity bile acid binding."J. Biol. Chem. 269:8416-8422(1994) [PubMed] [Europe PMC] [Abstract]
  3. "Regulation of human dihydrodiol dehydrogenase by Michael acceptor xenobiotics."J. Biol. Chem. 269:15558-15562(1994) [PubMed] [Europe PMC] [Abstract]
  4. "Distribution of 3 alpha-hydroxysteroid dehydrogenase in rat brain and molecular cloning of multiple cDNAs encoding structurally related proteins in humans."J. Steroid Biochem. Mol. Biol. 53:41-46(1995) [PubMed] [Europe PMC] [Abstract]
  5. "Close kinship of human 20alpha-hydroxysteroid dehydrogenase gene with three aldo-keto reductase genes."Genes Cells 5:111-125(2000) [PubMed] [Europe PMC] [Abstract]
  6. "Characterization of a human 20alpha-hydroxysteroid dehydrogenase."J. Mol. Endocrinol. 25:221-228(2000) [PubMed] [Europe PMC] [Abstract]
  7. "The DNA sequence and comparative analysis of human chromosome 10." Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Molecular cloning of multiple cDNAs encoding human enzymes structurally related to 3 alpha-hydroxysteroid dehydrogenase."J. Steroid Biochem. Mol. Biol. 46:673-679(1993) [PubMed] [Europe PMC] [Abstract]
  10. "Relationship of human liver dihydrodiol dehydrogenases to hepatic bile-acid-binding protein and an oxidoreductase of human colon cells."Biochem. J. 313:373-376(1996) [PubMed] [Europe PMC] [Abstract]
  11. "Molecular cloning of two human liver 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase isoenzymes that are identical with chlordecone reductase and bile-acid binder."Biochem. J. 299:545-552(1994) [PubMed] [Europe PMC] [Abstract]
  12. "Human 20alpha-hydroxysteroid dehydrogenase: crystallographic and site-directed mutagenesis studies lead to the identification of an alternative binding site for C21-steroids."J. Mol. Biol. 331:593-604(2003) [PubMed] [Europe PMC] [Abstract]
  13. "Probing the inhibitor selectivity pocket of human 20alpha-hydroxysteroid dehydrogenase (AKR1C1) with X-ray crystallography and site-directed mutagenesis."Bioorg. Med. Chem. Lett. 21:2564-2567(2011) [PubMed] [Europe PMC] [Abstract]