Acidic Nuclear Phosphoprotein 32 Family, Member A (ANP32A)

Lanp, which is 89% identical to the human protein and is expressed in cerebellum and brainstem. Binding analysis indicated that the strongest interaction between the proteins is with the N-terminal 147 residues on Lanp, which contain 5 leucine-rich repeats, and a full-length ataxin-1 containing 82 glutamines. Immunohistochemical analysis demonstrated highest levels of Lanp, like Atx1, in the nuclei of cerebellar Purkinje cells.Both proteins share extensive stretches of highly acidic amino acids in their terminal regions, which suggested a nuclear localization. Indeed, PHAP I is likely to be the human homolog of the rat 'leucine-rich acidic nuclear protein' (LANP) (83.6% identity), which is localized in the nuclei of Purkinje cells. Sequence identity demonstrated that PHAP II is identical to the protein encoded by the gene SET.