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B-Cell Translocation Gene 2 (BTG2)

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PC3; TIS21; BTG Family Member 2; NGF-Inducible Anti-Proliferative Protein PC3; NGF-Inducible Protein TIS21; Pheochromacytoma Cell-3

B-Cell Translocation Gene 2 (BTG2)
CCC J630
HGNC 1131
MGI 108384
PubMed 23299537
RGD 2225
UniProt P78543
Wiki BTG2
The protein BTG2 is the human homolog of the PC3 protein in rat and of the Tis21 protein in mouse.Tis21 had been originally isolated as a sequence induced by TPA in mouse fibroblasts, whereas PC3 was originally isolated as sequence induced at the beginning of neuron differentiation; BTG2 was then isolated in human cells as sequence induced by p53 and DNA damage.
BTG2 is a member of the BTG/Tob family . This family has structurally related proteins that appear to have antiproliferative properties. In particular, the BTG2 protein has been shown to negatively control a cell cycle checkpoint at the G1 to S phase transition in fibroblasts and neuronal cells by direct inhibition of the activity of cyclin D1 promoter.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant B-Cell Translocation Gene 2 (BTG2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to B-Cell Translocation Gene 2 (BTG2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to B-Cell Translocation Gene 2 (BTG2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for B-Cell Translocation Gene 2 (BTG2) CLIA Kit Customized Service Offer
n/a ELISA Kit for B-Cell Translocation Gene 2 (BTG2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant B-Cell Translocation Gene 2 (BTG2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to B-Cell Translocation Gene 2 (BTG2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to B-Cell Translocation Gene 2 (BTG2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for B-Cell Translocation Gene 2 (BTG2) CLIA Kit Customized Service Offer
n/a ELISA Kit for B-Cell Translocation Gene 2 (BTG2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant B-Cell Translocation Gene 2 (BTG2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to B-Cell Translocation Gene 2 (BTG2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to B-Cell Translocation Gene 2 (BTG2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for B-Cell Translocation Gene 2 (BTG2) CLIA Kit Customized Service Offer
n/a ELISA Kit for B-Cell Translocation Gene 2 (BTG2) ELISA Kit Customized Service Offer
  1. "Identification of BTG2, an antiproliferative p53-dependent component of the DNA damage cellular response pathway."Nat. Genet. 14:482-486(1996) [PubMed] [Europe PMC] [Abstract]
  2. "The gene PC3(TIS21/BTG2), prototype member of the PC3/BTG/TOB family: regulator in control of cell growth, differentiation, and DNA repair?"J. Cell. Physiol. 187:155-165(2001) [PubMed] [Europe PMC] [Abstract]
  3. "The human BTG2/TIS21/PC3 gene: genomic structure, transcriptional regulation and evaluation as a candidate tumor suppressor gene."Gene 282:207-214(2002) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Interaction of BTG1 and p53-regulated BTG2 gene products with mCaf1, the murine homolog of a component of the yeast CCR4 transcriptional regulatory complex."J. Biol. Chem. 273:22563-22569(1998) [PubMed] [Europe PMC] [Abstract]
  7. "Relationships of the antiproliferative proteins BTG1 and BTG2 with CAF1, the human homolog of a component of the yeast CCR4 transcriptional complex: involvement in estrogen receptor alpha signaling pathway."J. Biol. Chem. 276:9640-9648(2001) [PubMed] [Europe PMC] [Abstract]
  8. "BTG2 antiproliferative protein interacts with the human CCR4 complex existing in vivo in three cell-cycle-regulated forms."J. Cell Sci. 116:2929-2936(2003) [PubMed] [Europe PMC] [Abstract]
  9. "Phosphorylation of serine 147 of tis21/BTG2/pc3 by p-Erk1/2 induces Pin-1 binding in cytoplasm and cell death."J. Biol. Chem. 280:21256-21263(2005) [PubMed] [Europe PMC] [Abstract]
  10. "The BTG2 protein is a general activator of mRNA deadenylation."EMBO J. 27:1039-1048(2008) [PubMed] [Europe PMC] [Abstract]
  11. "PRMT1 and Btg2 regulates neurite outgrowth of Neuro2a cells."Neurosci. Lett. 445:162-165(2008) [PubMed] [Europe PMC] [Abstract]
  12. "The anti-proliferative activity of BTG/TOB proteins is mediated via the Caf1a (CNOT7) and Caf1b (CNOT8) deadenylase subunits of the Ccr4-not complex."PLoS ONE 7:E51331-E51331(2012) [PubMed] [Europe PMC] [Abstract]
  13. "Crystal structures of human BTG2 and mouse TIS21 involved in suppression of CAF1 deadenylase activity."Nucleic Acids Res. 36:6872-6881(2008) [PubMed] [Europe PMC] [Abstract]