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ADP Ribosylation Factor 6 (ARF6)

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ADP Ribosylation Factor 6 (ARF6)
CCC J626
HGNC 659
MGI 99435
PubMed 24297182
RGD 621279
UniProt P62330
Wiki Arf6
ARF6 is a member of the ADP ribosylation factor family of GTP-binding proteins. ARF6 has a variety of cellular functions that are frequently involved in trafficking of biological membranes and transmembrane protein cargo. ARF6 has specifically been implicated in endocytosis of plasma membrane proteins and also, to a lesser extent, plasma membrane protein recycling. ARF6 is part of the RAS superfamily. The ARF genes encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as activators of phospholipase D. The product of this gene is localized to the plasma membrane, and regulates vesicular trafficking, remodelling of membrane lipids, and signaling pathways that lead to actin remodeling.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant ADP Ribosylation Factor 6 (ARF6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to ADP Ribosylation Factor 6 (ARF6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to ADP Ribosylation Factor 6 (ARF6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for ADP Ribosylation Factor 6 (ARF6) CLIA Kit Customized Service Offer
n/a ELISA Kit for ADP Ribosylation Factor 6 (ARF6) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant ADP Ribosylation Factor 6 (ARF6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to ADP Ribosylation Factor 6 (ARF6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to ADP Ribosylation Factor 6 (ARF6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for ADP Ribosylation Factor 6 (ARF6) CLIA Kit Customized Service Offer
n/a ELISA Kit for ADP Ribosylation Factor 6 (ARF6) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant ADP Ribosylation Factor 6 (ARF6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to ADP Ribosylation Factor 6 (ARF6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to ADP Ribosylation Factor 6 (ARF6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for ADP Ribosylation Factor 6 (ARF6) CLIA Kit Customized Service Offer
n/a ELISA Kit for ADP Ribosylation Factor 6 (ARF6) ELISA Kit Customized Service Offer
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  2. "Sequence, genomic organization, and expression of the human ADP-ribosylation factor 6 (ARF6) gene: a class III ARF."DNA Cell Biol. 22:737-741(2003) [PubMed] [Europe PMC] [Abstract]
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  7. "ACAPs are arf6 GTPase-activating proteins that function in the cell periphery."J. Cell Biol. 151:627-638(2000) [PubMed] [Europe PMC] [Abstract]
  8. "ARF6 stimulates clathrin/AP-2 recruitment to synaptic membranes by activating phosphatidylinositol phosphate kinase type Igamma."J. Cell Biol. 162:113-124(2003) [PubMed] [Europe PMC] [Abstract]
  9. "The TBC (Tre-2/Bub2/Cdc16) domain protein TRE17 regulates plasma membrane-endosomal trafficking through activation of Arf6."Mol. Cell. Biol. 24:9752-9762(2004) [PubMed] [Europe PMC] [Abstract]
  10. "Regulation of dendritic branching and filopodia formation in hippocampal neurons by specific acylated protein motifs."Mol. Biol. Cell 15:2205-2217(2004) [PubMed] [Europe PMC] [Abstract]
  11. "Rab11-FIP3 and FIP4 interact with Arf6 and the exocyst to control membrane traffic in cytokinesis."EMBO J. 24:3389-3399(2005) [PubMed] [Europe PMC] [Abstract]
  12. "Requirement of phosphatidylinositol-4,5-bisphosphate for HERC1-mediated guanine nucleotide release from ARF proteins."FEBS Lett. 579:343-348(2005) [PubMed] [Europe PMC] [Abstract]
  13. "Golgi-localized GAP for Cdc42 functions downstream of ARF1 to control Arp2/3 complex and F-actin dynamics."Nat. Cell Biol. 7:353-364(2005) [PubMed] [Europe PMC] [Abstract]
  14. "Proteomic identification and functional characterization of a novel ARF6 GTPase-activating protein, ACAP4."Mol. Cell. Proteomics 5:1437-1449(2006) [PubMed] [Europe PMC] [Abstract]
  15. "Structural basis for Rab11-dependent membrane recruitment of a family of Rab11-interacting protein 3 (FIP3)/Arfophilin-1."Proc. Natl. Acad. Sci. U.S.A. 103:15416-15421(2006) [PubMed] [Europe PMC] [Abstract]
  16. "The Arl4 family of small G proteins can recruit the cytohesin Arf6 exchange factors to the plasma membrane."Curr. Biol. 17:711-716(2007) [PubMed] [Europe PMC] [Abstract]
  17. "Molecular characterization of Rab11-FIP3 binding to ARF GTPases."Eur. J. Cell Biol. 86:417-431(2007) [PubMed] [Europe PMC] [Abstract]
  18. "Specificity, promiscuity and localization of ARF protein interactions with NCS-1 and phosphatidylinositol-4 kinase-III beta."Traffic 8:1080-1092(2007) [PubMed] [Europe PMC] [Abstract]
  19. "ASAP3 is a focal adhesion-associated Arf GAP that functions in cell migration and invasion."J. Biol. Chem. 283:14915-14926(2008) [PubMed] [Europe PMC] [Abstract]
  20. "TBC1D24, an ARF6-interacting protein, is mutated in familial infantile myoclonic epilepsy."Am. J. Hum. Genet. 87:365-370(2010) [PubMed] [Europe PMC] [Abstract]
  21. "AIP1 functions as Arf6-GAP to negatively regulate TLR4 signaling."J. Biol. Chem. 285:3750-3757(2010) [PubMed] [Europe PMC] [Abstract]
  22. "A protein interaction network for Ecm29 links the 26 S proteasome to molecular motors and endosomal components."J. Biol. Chem. 285:31616-31633(2010) [PubMed] [Europe PMC] [Abstract]
  23. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  24. "MICAL-L1 is a tubular endosomal membrane hub that connects Rab35 and Arf6 with Rab8a."Traffic 13:82-93(2012) [PubMed] [Europe PMC] [Abstract]
  25. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  26. "Structure of Arf6-GDP suggests a basis for guanine nucleotide exchange factors specificity."Nat. Struct. Biol. 7:466-469(2000) [PubMed] [Europe PMC] [Abstract]
  27. "The structural GDP/GTP cycle of human Arf6."EMBO Rep. 2:234-238(2001) [PubMed] [Europe PMC] [Abstract]
  28. "Structural basis for the activation of cholera toxin by human ARF6-GTP."Science 309:1093-1096(2005) [PubMed] [Europe PMC] [Abstract]
  29. "NMR structural studies of the myristoylated N-terminus of ADP ribosylation factor 6 (Arf6)."FEBS Lett. 580:4296-4301(2006) [PubMed] [Europe PMC] [Abstract]
  30. "The structural basis of Arf effector specificity: the crystal structure of ARF6 in a complex with JIP4."EMBO J. 28:2835-2845(2009) [PubMed] [Europe PMC] [Abstract]
  31. "The structure of an Arf-ArfGAP complex reveals a Ca2+ regulatory mechanism."Cell 141:812-821(2010) [PubMed] [Europe PMC] [Abstract]
  32. "The assembly of a GTPase-kinase signalling complex by a bacterial catalytic scaffold."Nature 469:107-111(2011) [PubMed] [Europe PMC] [Abstract]
  33. "Structurally distinct bacterial TBC-like GAPs link Arf GTPase to Rab1 inactivation to counteract host defenses."Cell 150:1029-1041(2012) [PubMed] [Europe PMC] [Abstract]
  34. "Structural basis for membrane recruitment and allosteric activation of cytohesin family Arf GTPase exchange factors."Proc. Natl. Acad. Sci. U.S.A. 110:14213-14218(2013) [PubMed] [Europe PMC] [Abstract]