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ADP Ribosylation Factor GTPase Activating Protein 2 (ARFGAP2)

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ZNF289; IRZ; Zinc Finger Protein 289,ID1 Regulated; GTPase-activating protein ZNF289

ADP Ribosylation Factor GTPase Activating Protein 2 (ARFGAP2)
CCC J618
HGNC 13504
MGI 1924288
PubMed 19015319
RGD 1306177
UniProt Q8N6H7
Znf289 mRNA expression paralleled that of Id1 during mouse mammary gland development, with Znf289 expressed during ductal and lobuloalveolar morphogenesis when there is extensive proliferation of mammary epithelial cells. It is downregulated following the decrease in Id1 expression in differentiated, growth-arrested lactating epithelial cells.
Human ARFGAP2 lacking its N-terminal zinc finger domain bound COPI subunits, and expression of this truncated mutant inhibited COPI-dependent Golgi-to-endoplasmic reticulum transport of cholera toxin in vivo. Silencing of ARFGAP1 or a combination of ARFGAP2 and ARFGAP3 in HeLa cells did not decrease cell viability, but silencing of all 3 ARFGAPs caused cell death.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant ADP Ribosylation Factor GTPase Activating Protein 2 (ARFGAP2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to ADP Ribosylation Factor GTPase Activating Protein 2 (ARFGAP2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to ADP Ribosylation Factor GTPase Activating Protein 2 (ARFGAP2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for ADP Ribosylation Factor GTPase Activating Protein 2 (ARFGAP2) CLIA Kit Customized Service Offer
n/a ELISA Kit for ADP Ribosylation Factor GTPase Activating Protein 2 (ARFGAP2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant ADP Ribosylation Factor GTPase Activating Protein 2 (ARFGAP2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to ADP Ribosylation Factor GTPase Activating Protein 2 (ARFGAP2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to ADP Ribosylation Factor GTPase Activating Protein 2 (ARFGAP2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for ADP Ribosylation Factor GTPase Activating Protein 2 (ARFGAP2) CLIA Kit Customized Service Offer
n/a ELISA Kit for ADP Ribosylation Factor GTPase Activating Protein 2 (ARFGAP2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant ADP Ribosylation Factor GTPase Activating Protein 2 (ARFGAP2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to ADP Ribosylation Factor GTPase Activating Protein 2 (ARFGAP2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to ADP Ribosylation Factor GTPase Activating Protein 2 (ARFGAP2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for ADP Ribosylation Factor GTPase Activating Protein 2 (ARFGAP2) CLIA Kit Customized Service Offer
n/a ELISA Kit for ADP Ribosylation Factor GTPase Activating Protein 2 (ARFGAP2) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "Human chromosome 11 DNA sequence and analysis including novel gene identification." Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  5. "Neuroblastoma oligo-capping cDNA project: toward the understanding of the genesis and biology of neuroblastoma."Cancer Lett. 197:63-68(2003) [PubMed] [Europe PMC] [Abstract]
  6. "Gamma-COP appendage domain -- structure and function."Traffic 5:79-88(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Two human ARFGAPs associated with COP-I-coated vesicles."Traffic 8:1644-1655(2007) [PubMed] [Europe PMC] [Abstract]
  8. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  9. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  12. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  13. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  14. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  15. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  16. "Gap domain of ZNF289, an ID1-regulated zinc finger protein."Submitted (MAR-2007) to the PDB data bank