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ADP Ribosylation Factor GTPase Activating Protein 3 (ARFGAP3)

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ADP Ribosylation Factor GTPase Activating Protein 3 (ARFGAP3)
CCC J617
HGNC 661
MGI 1913501
PubMed 21647875
UniProt Q9NP61
Wiki ARFGAP3
ARFGAP3 is a GTPase-activating protein (GAP) which associates with the Golgi apparatus and which is thought to interact with ADP-ribosylation factor 1 (ARF1). The encoded protein likely promotes hydrolysis of ARF1-bound GTP, which is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles. Dissociation of the coat proteins is a prerequisite for the fusion of these vesicles with target compartments. The activity of this protein is sensitive to phospholipids. This gene was originally known as ARFGAP1, but that is now the name of a related but different gene.
Widely expressed. Highest expression in endocrine glands (pancreas, pituary gland, salivary gland, and prostate) and testis with a much higher expression in the testis than in the ovary.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant ADP Ribosylation Factor GTPase Activating Protein 3 (ARFGAP3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to ADP Ribosylation Factor GTPase Activating Protein 3 (ARFGAP3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to ADP Ribosylation Factor GTPase Activating Protein 3 (ARFGAP3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for ADP Ribosylation Factor GTPase Activating Protein 3 (ARFGAP3) CLIA Kit Customized Service Offer
n/a ELISA Kit for ADP Ribosylation Factor GTPase Activating Protein 3 (ARFGAP3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant ADP Ribosylation Factor GTPase Activating Protein 3 (ARFGAP3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to ADP Ribosylation Factor GTPase Activating Protein 3 (ARFGAP3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to ADP Ribosylation Factor GTPase Activating Protein 3 (ARFGAP3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for ADP Ribosylation Factor GTPase Activating Protein 3 (ARFGAP3) CLIA Kit Customized Service Offer
n/a ELISA Kit for ADP Ribosylation Factor GTPase Activating Protein 3 (ARFGAP3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant ADP Ribosylation Factor GTPase Activating Protein 3 (ARFGAP3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to ADP Ribosylation Factor GTPase Activating Protein 3 (ARFGAP3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to ADP Ribosylation Factor GTPase Activating Protein 3 (ARFGAP3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for ADP Ribosylation Factor GTPase Activating Protein 3 (ARFGAP3) CLIA Kit Customized Service Offer
n/a ELISA Kit for ADP Ribosylation Factor GTPase Activating Protein 3 (ARFGAP3) ELISA Kit Customized Service Offer
  1. "Characterization, chromosomal assignment, and tissue expression of a novel human gene belonging to the ARF GAP family."Genomics 63:400-408(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Reevaluating human gene annotation: a second-generation analysis of chromosome 22."Genome Res. 13:27-36(2003) [PubMed] [Europe PMC] [Abstract]
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  4. "The DNA sequence of human chromosome 22." Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
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  6. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  7. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Functional characterization of novel human ARFGAP3."FEBS Lett. 490:79-83(2001) [PubMed] [Europe PMC] [Abstract]
  9. "Two human ARFGAPs associated with COP-I-coated vesicles."Traffic 8:1644-1655(2007) [PubMed] [Europe PMC] [Abstract]
  10. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  13. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  14. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  15. "Solution structure of the ARFGAP domain of ADP-ribosylation factor GTPase-activating protein 3 (ARFGAP 3)."Submitted (NOV-2005) to the PDB data bank
  16. "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
  17. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]