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ADP Ribosylation Factor Like Protein 6 (ARL6)

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BBS3; Bardet-Biedl syndrome 3 protein

ADP Ribosylation Factor Like Protein 6 (ARL6)
CCC J616
HGNC 13210
MGI 1927136
PubMed 20207729
RGD 1305535
UniProt Q9H0F7
Wiki ARL6
ARL6 belongs to the ARF family of GTP-binding proteins. ARF proteins are important regulators of cellular traffic and are the founding members of an expanding family of homologous proteins and genomic sequences. They depart from other small GTP-binding proteins by a unique structural device that implements front-back communication from the N-terminus to the nucleotide-binding site. Studies of the mouse ortholog of this protein suggest an involvement in protein transport, membrane trafficking, or cell signaling during hematopoietic maturation.
Alternative splicing occurs at this locus and two transcript variants encoding the same protein have been described.The deduced 186-amino acid protein has a calculated molecular mass of 20.9 kD.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant ADP Ribosylation Factor Like Protein 6 (ARL6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to ADP Ribosylation Factor Like Protein 6 (ARL6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to ADP Ribosylation Factor Like Protein 6 (ARL6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for ADP Ribosylation Factor Like Protein 6 (ARL6) CLIA Kit Customized Service Offer
n/a ELISA Kit for ADP Ribosylation Factor Like Protein 6 (ARL6) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant ADP Ribosylation Factor Like Protein 6 (ARL6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to ADP Ribosylation Factor Like Protein 6 (ARL6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to ADP Ribosylation Factor Like Protein 6 (ARL6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for ADP Ribosylation Factor Like Protein 6 (ARL6) CLIA Kit Customized Service Offer
n/a ELISA Kit for ADP Ribosylation Factor Like Protein 6 (ARL6) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant ADP Ribosylation Factor Like Protein 6 (ARL6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to ADP Ribosylation Factor Like Protein 6 (ARL6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to ADP Ribosylation Factor Like Protein 6 (ARL6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for ADP Ribosylation Factor Like Protein 6 (ARL6) CLIA Kit Customized Service Offer
n/a ELISA Kit for ADP Ribosylation Factor Like Protein 6 (ARL6) ELISA Kit Customized Service Offer
  1. "Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence, annotation and analysis of human chromosome 3." Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Comparative genomic analysis identifies an ADP-ribosylation factor-like gene as the cause of Bardet-Biedl Syndrome (BBS3)."Am. J. Hum. Genet. 75:475-484(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The conserved Bardet-Biedl syndrome proteins assemble a coat that traffics membrane proteins to cilia."Cell 141:1208-1219(2010) [PubMed] [Europe PMC] [Abstract]
  7. "Identification and functional analysis of the vision-specific BBS3 (ARL6) long isoform."PLoS Genet. 6:E1000884-E1000884(2010) [PubMed] [Europe PMC] [Abstract]
  8. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  9. "A novel protein LZTFL1 regulates ciliary trafficking of the BBSome and Smoothened."PLoS Genet. 7:E1002358-E1002358(2011) [PubMed] [Europe PMC] [Abstract]
  10. "The intraflagellar transport protein IFT27 promotes BBSome exit from cilia through the GTPase ARL6/BBS3."Dev. Cell 31:265-278(2014) [PubMed] [Europe PMC] [Abstract]
  11. "Bardet-Biedl syndrome-associated small GTPase ARL6 (BBS3) functions at or near the ciliary gate and modulates Wnt signaling."J. Biol. Chem. 285:16218-16230(2010) [PubMed] [Europe PMC] [Abstract]
  12. "Mutations in a member of the Ras superfamily of small GTP-binding proteins causes Bardet-Biedl syndrome."Nat. Genet. 36:989-993(2004) [PubMed] [Europe PMC] [Abstract]
  13. "Biochemical characterization of missense mutations in the Arf/Arl-family small GTPase Arl6 causing Bardet-Biedl syndrome."Biochem. Biophys. Res. Commun. 381:439-442(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Molecular characterization of retinitis pigmentosa in Saudi Arabia."Mol. Vis. 15:2464-2469(2009) [PubMed] [Europe PMC] [Abstract]
  15. "Novel homozygous mutations in the genes ARL6 and BBS10 underlying Bardet-Biedl syndrome."Gene 515:84-88(2013) [PubMed] [Europe PMC] [Abstract]