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Arsenic, 3-Oxidation State Methyltransferase (AS3MT)

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CYT19; Arsenite Methyltransferase; Methylarsonite methyltransferase; S-adenosyl-L-methionine:arsenic(III) methyltransferase

Arsenic, 3-Oxidation State Methyltransferase (AS3MT)
CCC J595
HGNC 17452
MGI 1929882
PubMed 16407288
RGD 621325
UniProt Q9HBK9
Wiki AS3MT
AS3MT catalyzes the transfer of a methyl group from S-adenosyl-L-methionine (AdoMet) to trivalent arsenical and may play a role in arsenic metabolism . AS3MT encodes a 375-amino acid protein with 76% amino acid identity to rat As3mt.
The deduced 369-amino acid rat protein has a calculated molecular mass of about 41 kD and contains 2 methyltransferase motifs. RT-PCR analysis of adult rat tissues detected expression in heart, adrenal, urinary bladder, brain, kidney, lung, and liver. Human AS3MT was expressed in a hepatoma cell line but not in an immortalized human urothelial cell line. Recombinant rat As3mt catalyzed the transfer of methyl groups from AdoMet to trivalent arsenicals, resulting in methylated and dimethylated arsenicals.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Arsenic, 3-Oxidation State Methyltransferase (AS3MT) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Arsenic, 3-Oxidation State Methyltransferase (AS3MT) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Arsenic, 3-Oxidation State Methyltransferase (AS3MT) Polyclonal Antibody Customized Service Offer
Assay Kits SEJ595Hu ELISA Kit for Arsenic, 3-Oxidation State Methyltransferase (AS3MT) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Arsenic, 3-Oxidation State Methyltransferase (AS3MT) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Arsenic, 3-Oxidation State Methyltransferase (AS3MT) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Arsenic, 3-Oxidation State Methyltransferase (AS3MT) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Arsenic, 3-Oxidation State Methyltransferase (AS3MT) CLIA Kit Customized Service Offer
n/a ELISA Kit for Arsenic, 3-Oxidation State Methyltransferase (AS3MT) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Arsenic, 3-Oxidation State Methyltransferase (AS3MT) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Arsenic, 3-Oxidation State Methyltransferase (AS3MT) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Arsenic, 3-Oxidation State Methyltransferase (AS3MT) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Arsenic, 3-Oxidation State Methyltransferase (AS3MT) CLIA Kit Customized Service Offer
n/a ELISA Kit for Arsenic, 3-Oxidation State Methyltransferase (AS3MT) ELISA Kit Customized Service Offer
  1. "Human arsenic methyltransferase (AS3MT) pharmacogenetics: gene resequencing and functional genomics studies."J. Biol. Chem. 281:7364-7373(2006) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and comparative analysis of human chromosome 10." Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  5. "Alternative splicing variants of human arsenic (+3 oxidation state) methyltransferase."Biochem. Biophys. Res. Commun. 415:48-53(2011) [PubMed] [Europe PMC] [Abstract]
  6. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  7. "High arsenic metabolic efficiency in AS3MT287Thr allele carriers."Pharmacogenet. Genomics 18:349-355(2008) [PubMed] [Europe PMC] [Abstract]