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Members of the MAGE, GAGE, and BAGE gene families encode antigens recognized by cytotoxic T lymphocytes. These antigens are also known as CT antigens for their expression in cancer cells and testis.
BAGE, encoding a 43-amino acid peptide unrelated to the MAGE family. Southern blot analysis indicated that BAGE belongs to a family of several related genes. Northern analysis of polyA(+) RNA from MZ2-MEL.43 cells identified a 1-kb and a 2.4-kb transcript. Similar to other CT antigen genes, expression of BAGE in normal tissues was observed only in adult testis. BAGE was expressed in 22% of melanomas, 30% of infiltrating bladder carcinomas, 10% of mammary carcinomas, 8% of head and neck squamous cell carcinomas, and 6% of non-small cell lung carcinomas.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant B-Melanoma Antigen (BAGE) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to B-Melanoma Antigen (BAGE) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to B-Melanoma Antigen (BAGE) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for B-Melanoma Antigen (BAGE) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for B-Melanoma Antigen (BAGE) | ELISA Kit Customized Service Offer |
- "BAGE: a new gene encoding an antigen recognized on human melanomas by cytolytic T lymphocytes."Immunity 2:167-175(1995) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "New BAGE (B melanoma antigen) genes mapping to the juxtacentromeric regions of human chromosomes 13 and 21 have a cancer/testis expression profile."Eur. J. Hum. Genet. 10:833-840(2002) [PubMed] [Europe PMC] [Abstract]