Bridging Integrator 3 (BIN3)

BIN3 is a member of the BAR domain protein family. The encoded protein is comprised solely of a BAR domain which is predicted to form coiled-coil structures and proposed to mediate dimerization, sense and induce membrane curvature, and bind small GTPases. BAR domain proteins have been implicated in endocytosis, intracellular transport, and a diverse set of other processes.

The deduced 253-amino acid protein, like its yeast counterpart, is composed solely of a BAR domain. In contrast, the BAR family members AMPH and BIN2 are expressed primarily in brain and hematopoietic tissues, respectively. Like BIN3, BIN1 is widely expressed; however, BIN1 expression is decreased in tumor cells, while BIN3 expression is not.