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Brain Selective Kinase 1 (BRSK1)

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SAD1; SADB; Brain-specific serine/threonine-protein kinase 1; Synapses of Amphids Defective homolog 1; Serine/threonine-protein kinase BRSK1; BR serine/threonine kinase 1

Brain Selective Kinase 1 (BRSK1)
CCC J529
HGNC 18994
MGI 2685946
PubMed 22248077
RGD 1563268
UniProt Q8TDC3
Wiki BRSK1
By sequencing clones obtained from a size-fractionated adult brain cDNA library, Nagase et al. (2001) cloned BRSK1, which they designated KIAA1811. The deduced 715-amino acid protein shares 75% identity with BRSK2. The first methionine was not found within a Kozak context, indicating the cDNA may be incomplete. RT-PCR ELISA detected highest expression in adult brain, followed by fetal brain and adult spinal cord. Intermediate expression was detected in adult heart, pancreas, testis, ovary, lung, and kidney, and in fetal liver. Adult liver, spleen, and skeletal muscle showed little to no expression. All specific adult brain regions examined showed intermediate to high BRSK1 expression, with highest levels in caudate nucleus and substantia nigra.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Brain Selective Kinase 1 (BRSK1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Brain Selective Kinase 1 (BRSK1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Brain Selective Kinase 1 (BRSK1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Brain Selective Kinase 1 (BRSK1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Brain Selective Kinase 1 (BRSK1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Brain Selective Kinase 1 (BRSK1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Brain Selective Kinase 1 (BRSK1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Brain Selective Kinase 1 (BRSK1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Brain Selective Kinase 1 (BRSK1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Brain Selective Kinase 1 (BRSK1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Brain Selective Kinase 1 (BRSK1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Brain Selective Kinase 1 (BRSK1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Brain Selective Kinase 1 (BRSK1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Brain Selective Kinase 1 (BRSK1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Brain Selective Kinase 1 (BRSK1) ELISA Kit Customized Service Offer
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  11. "Persistence of the cell-cycle checkpoint kinase Wee1 in SadA- and SadB-deficient neurons disrupts neuronal polarity."J. Cell Sci. 123:286-294(2010) [PubMed] [Europe PMC] [Abstract]
  12. "Phosphorylation of microtubule-associated protein tau by AMPK-related kinases."J. Neurochem. 120:165-176(2012) [PubMed] [Europe PMC] [Abstract]
  13. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]