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LIM Domain Binding Protein 1 (LDB1)

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CLIM2; NLI; Carboxy Terminal LIM Domain Protein 2; LIM domain-binding factor CLIM2; Nuclear LIM interactor

LIM Domain Binding Protein 1 (LDB1)
CCC J524
HGNC 6532
MGI 894762
PubMed 23610375
RGD 1310359
UniProt Q86U70
Wiki LDB1
CLIM1 and CLIM2 have a very high level of identity to each other and to the homologs in other species.CLIM2 encodes a 375-amino acid protein.human LMO2 interacted with human BEX2. Electrophoretic mobility shift assays showed that BEX2 and LMO2 were part of a DNA-binding complex that recognized the E-box element. Other components of this complex included NSCL2 (NHLH2) and LDB1.
LDB1 associated with a complex containing LMO4, CTIP, and BRCA1 in transfected human embryonic kidney cells.LDB1 was consistently enriched in the superior temporal gyrus posterior temporal cortex, and perisylvian cortex. LDB1 may be involved in asymmetric patterning of the developing human cortex.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPJ524Hu01 Recombinant LIM Domain Binding Protein 1 (LDB1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAJ524Hu21 Monoclonal Antibody to LIM Domain Binding Protein 1 (LDB1) WB; IHC; ICC; IP.
PAJ524Hu01 Polyclonal Antibody to LIM Domain Binding Protein 1 (LDB1) WB
Assay Kits SEJ524Hu ELISA Kit for LIM Domain Binding Protein 1 (LDB1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant LIM Domain Binding Protein 1 (LDB1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to LIM Domain Binding Protein 1 (LDB1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to LIM Domain Binding Protein 1 (LDB1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for LIM Domain Binding Protein 1 (LDB1) CLIA Kit Customized Service Offer
n/a ELISA Kit for LIM Domain Binding Protein 1 (LDB1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant LIM Domain Binding Protein 1 (LDB1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to LIM Domain Binding Protein 1 (LDB1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to LIM Domain Binding Protein 1 (LDB1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for LIM Domain Binding Protein 1 (LDB1) CLIA Kit Customized Service Offer
n/a ELISA Kit for LIM Domain Binding Protein 1 (LDB1) ELISA Kit Customized Service Offer
  1. "Cloning and chromosomal localization of two novel human genes encoding LIM-domain binding factors CLIM1 and CLIM2/LDB1/NLI."Mamm. Genome 9:921-924(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Genomic structure, alternative transcripts and chromosome location of the human LIM domain binding protein gene LDB1."Cytogenet. Cell Genet. 87:119-124(1999) [PubMed] [Europe PMC] [Abstract]
  3. "Isolation and chromosomal assignment of human genes encoding cofactor of LIM homeodomain proteins, CLIM1 and CLIM2."J. Hum. Genet. 44:112-115(1999) [PubMed] [Europe PMC] [Abstract]
  4. "Spliced isoforms of LIM-domain-binding protein (CLIM/NLI/Ldb) lacking the LIM-interaction domain."J. Biochem. 140:105-119(2006) [PubMed] [Europe PMC] [Abstract]
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The DNA sequence and comparative analysis of human chromosome 10." Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Regulation of estrogen-dependent transcription by the LIM cofactors CLIM and RLIM in breast cancer."Cancer Res. 69:128-136(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  11. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  12. "Structure of the leukemia oncogene LMO2: implications for the assembly of a hematopoietic transcription factor complex."Blood 117:2146-2156(2011) [PubMed] [Europe PMC] [Abstract]
  13. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]