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Large Tumor Suppressor Homolog 1 (LATS1)

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WARTS; Wts; WARTS protein kinase; Serine/threonine-protein kinase LATS1

Large Tumor Suppressor Homolog 1 (LATS1)
CCC J513
HGNC 6514
MGI 1333883
PubMed 12379777
RGD 1564085
UniProt O95835
Wiki LATS1
LATS1 is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Large Tumor Suppressor Homolog 1 (LATS1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Large Tumor Suppressor Homolog 1 (LATS1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Large Tumor Suppressor Homolog 1 (LATS1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Large Tumor Suppressor Homolog 1 (LATS1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Large Tumor Suppressor Homolog 1 (LATS1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Large Tumor Suppressor Homolog 1 (LATS1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Large Tumor Suppressor Homolog 1 (LATS1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Large Tumor Suppressor Homolog 1 (LATS1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Large Tumor Suppressor Homolog 1 (LATS1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Large Tumor Suppressor Homolog 1 (LATS1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Large Tumor Suppressor Homolog 1 (LATS1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Large Tumor Suppressor Homolog 1 (LATS1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Large Tumor Suppressor Homolog 1 (LATS1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Large Tumor Suppressor Homolog 1 (LATS1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Large Tumor Suppressor Homolog 1 (LATS1) ELISA Kit Customized Service Offer
  1. "Human homologue of the Drosophila melanogaster lats tumour suppressor modulates CDC2 activity."Nat. Genet. 21:177-181(1999) [PubMed] [Europe PMC] [Abstract].
  2. "A human homolog of Drosophila warts tumor suppressor, h-warts, localized to mitotic apparatus and specifically phosphorylated during mitosis."FEBS Lett. 459:159-165(1999) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract].
  4. "Zyxin, a regulator of actin filament assembly, targets the mitotic apparatus by interacting with h-warts/LATS1 tumor suppressor."J. Cell Biol. 149:1073-1086(2000) [PubMed] [Europe PMC] [Abstract]
  5. "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry."Anal. Chem. 76:2763-2772(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Tumor suppressor WARTS ensures genomic integrity by regulating both mitotic progression and G1 tetraploidy checkpoint function."Oncogene 23:5266-5274(2004) [PubMed] [Europe PMC] [Abstract]
  7. "LATS1 tumour suppressor affects cytokinesis by inhibiting LIMK1."Nat. Cell Biol. 6:609-617(2004) [PubMed] [Europe PMC] [Abstract]
  8. "The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1."Oncogene 24:2076-2086(2005) [PubMed] [Europe PMC] [Abstract]
  9. "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
  10. "Tumor suppressor LATS1 is a negative regulator of oncogene YAP."J. Biol. Chem. 283:5496-5509(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  12. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  13. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  15. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  16. "Ajuba LIM proteins are negative regulators of the Hippo signaling pathway."Curr. Biol. 20:657-662(2010) [PubMed] [Europe PMC] [Abstract]
  17. "Molecular characterization of human homologs of yeast MOB1."Int. J. Cancer 126:2079-2089(2010) [PubMed] [Europe PMC] [Abstract]
  18. "Regulation of ploidy and senescence by the AMPK-related kinase NUAK1."EMBO J. 29:376-386(2010) [PubMed] [Europe PMC] [Abstract]
  19. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  20. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]