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LIM Domain And Actin Binding Protein 1 (LIMA1)

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EPLIN; SREBP3; Epithelial Protein Lost In Neoplasm Beta; Epithelial protein lost in neoplasm

LIM Domain And Actin Binding Protein 1 (LIMA1)
CCC J507
HGNC 24636
MGI 1920992
PubMed 10806352
RGD 1564050
UniProt Q9UHB6
Wiki LIMA1
EPLIN is a cytoskeleton-associated protein that inhibits actin filament depolymerization and cross-links filaments in bundles.EPLIN-alpha was either downregulated or lost in 8 of 8 oral cancer cell lines, 4 of 4 prostate cancer cell lines, 3 of 3 xenograft tumors, and 5 of 6 breast cancer cell lines tested.
EPLIN-alpha encodes a deduced 600-amino acid protein, and EPLIN-beta encodes a deduced 759-amino acid protein. Both proteins contain a centrally located LIM domain that is distantly related to the LIM domain of muscle LIM protein. Northern blot analysis detected the 2 EPLIN transcripts at about 3.8 kb. Highest expression was in placenta, followed by kidney, pancreas, prostate, ovary, spleen, and heart; low expression was detected in all other tissues.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant LIM Domain And Actin Binding Protein 1 (LIMA1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to LIM Domain And Actin Binding Protein 1 (LIMA1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to LIM Domain And Actin Binding Protein 1 (LIMA1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for LIM Domain And Actin Binding Protein 1 (LIMA1) CLIA Kit Customized Service Offer
n/a ELISA Kit for LIM Domain And Actin Binding Protein 1 (LIMA1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant LIM Domain And Actin Binding Protein 1 (LIMA1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to LIM Domain And Actin Binding Protein 1 (LIMA1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to LIM Domain And Actin Binding Protein 1 (LIMA1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for LIM Domain And Actin Binding Protein 1 (LIMA1) CLIA Kit Customized Service Offer
n/a ELISA Kit for LIM Domain And Actin Binding Protein 1 (LIMA1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant LIM Domain And Actin Binding Protein 1 (LIMA1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to LIM Domain And Actin Binding Protein 1 (LIMA1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to LIM Domain And Actin Binding Protein 1 (LIMA1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for LIM Domain And Actin Binding Protein 1 (LIMA1) CLIA Kit Customized Service Offer
n/a ELISA Kit for LIM Domain And Actin Binding Protein 1 (LIMA1) ELISA Kit Customized Service Offer
  1. "EPLIN, epithelial protein lost in neoplasm."Oncogene 18:7838-7841(1999) [PubMed] [Europe PMC] [Abstract]
  2. "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning." Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Large-scale cDNA transfection screening for genes related to cancer development and progression." Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing."EMBO Rep. 1:287-292(2000) [PubMed] [Europe PMC] [Abstract]
  8. "Characterization of the human EPLIN (Epithelial protein lost in neoplasm) gene reveals distinct promoters for the two EPLIN isoforms."Gene 248:69-76(2000) [PubMed] [Europe PMC] [Abstract]
  9. "EPLIN regulates actin dynamics by cross-linking and stabilizing filaments."J. Cell Biol. 160:399-407(2003) [PubMed] [Europe PMC] [Abstract]
  10. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  11. "Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."J. Proteome Res. 6:4150-4162(2007) [PubMed] [Europe PMC] [Abstract]
  12. "Phosphoproteome of resting human platelets."J. Proteome Res. 7:526-534(2008) [PubMed] [Europe PMC] [Abstract]
  13. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  14. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  15. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  16. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  17. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  18. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  19. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  20. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  21. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  22. "Solution structure of the LIM domain of epithelial protein lost in neoplasm."Submitted (JUN-2006) to the PDB data bank