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Coactivator Associated Arginine Methyltransferase 1 (CARM1)

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PRMT4; Histone-arginine methyltransferase CARM1; Protein arginine N-methyltransferase 4

Coactivator Associated Arginine Methyltransferase 1 (CARM1)
CCC J493
HGNC 23393
MGI 1913208
PubMed 24434208
UniProt Q86X55
Wiki CARM1
CARM1 (coactivator-associated arginine methyltransferase 1) is an enzyme (EC 2.1.1.125) encoded by the CARM1 gene found in human beings, as well as many other mammals.CARM1 is a secondary coactivator through its association with p160 family (SRC-1, GRIP1, AIB) of coactivators. It is responsible for moving cells toward the inner cell mass in developing blastocysts. This gene also plays an important role in androgen receptors and may play a role in prostate cancer progression.The central portion of the coding region had extensive homology to a family of proteins with arginine-specific protein methyltransferase activity. The protein, coactivator-associated arginine methyltransferase-1 (CARM1), has a 3.8-kb mRNA that is widely but not evenly expressed in adult mouse tissues.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Coactivator Associated Arginine Methyltransferase 1 (CARM1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Coactivator Associated Arginine Methyltransferase 1 (CARM1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Coactivator Associated Arginine Methyltransferase 1 (CARM1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Coactivator Associated Arginine Methyltransferase 1 (CARM1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Coactivator Associated Arginine Methyltransferase 1 (CARM1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Coactivator Associated Arginine Methyltransferase 1 (CARM1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Coactivator Associated Arginine Methyltransferase 1 (CARM1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Coactivator Associated Arginine Methyltransferase 1 (CARM1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Coactivator Associated Arginine Methyltransferase 1 (CARM1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Coactivator Associated Arginine Methyltransferase 1 (CARM1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Coactivator Associated Arginine Methyltransferase 1 (CARM1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Coactivator Associated Arginine Methyltransferase 1 (CARM1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Coactivator Associated Arginine Methyltransferase 1 (CARM1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Coactivator Associated Arginine Methyltransferase 1 (CARM1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Coactivator Associated Arginine Methyltransferase 1 (CARM1) ELISA Kit Customized Service Offer
  1. "The DNA sequence and biology of human chromosome 19." Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  4. "Lipopolysaccharide-induced methylation of HuR, an mRNA-stabilizing protein, by CARM1. Coactivator-associated arginine methyltransferase."J. Biol. Chem. 277:44623-44630(2002) [PubMed] [Europe PMC] [Abstract]
  5. "Aberrant expression of CARM1, a transcriptional coactivator of androgen receptor, in the development of prostate carcinoma and androgen-independent status."Cancer 101:83-89(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Ligand-dependent activation of the farnesoid X-receptor directs arginine methylation of histone H3 by CARM1."J. Biol. Chem. 279:54348-54357(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Regulation of coactivator complex assembly and function by protein arginine methylation and demethylimination."Proc. Natl. Acad. Sci. U.S.A. 102:3611-3616(2005) [PubMed] [Europe PMC] [Abstract]
  8. "Coactivator-associated arginine methyltransferase 1 enhances transcriptional activity of the human T-cell lymphotropic virus type 1 long terminal repeat through direct interaction with Tax."J. Virol. 80:10036-10044(2006) [PubMed] [Europe PMC] [Abstract]
  9. "Coactivator-associated arginine methyltransferase-1 enhances nuclear factor-kappaB-mediated gene transcription through methylation of histone H3 at arginine 17."Mol. Endocrinol. 20:1562-1573(2006) [PubMed] [Europe PMC] [Abstract]
  10. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Kinetic analysis of human protein arginine N-methyltransferase 2: formation of monomethyl- and asymmetric dimethyl-arginine residues on histone H4."Biochem. J. 421:253-261(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Biochemical control of CARM1 enzymatic activity by phosphorylation."J. Biol. Chem. 284:36167-36174(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  14. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
  15. "Structural basis for CARM1 inhibition by indole and pyrazole inhibitors."Biochem. J. 436:331-339(2011) [PubMed] [Europe PMC] [Abstract]