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Calcium Uptake Protein 1, Mitochondrial (MICU1)

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CBARA1; CALC; EFHA3; ARACALC; Atopy-Related IgE Autoantigen With A Calcium-Binding Domain; Calcium Binding Atopy Related Autoantigen 1; Atopy-related autoantigen CALC

Calcium Uptake Protein 1, Mitochondrial (MICU1)
CCC J485
HGNC 1530
MGI 2384909
PubMed 21685888
RGD 735033
UniProt Q9BPX6
Wiki CBARA1
Mitochondrial calcium uptake is present in nearly all vertebrate tissues and is believed to be critical in shaping calcium signaling, regulating ATP synthesis and controlling cell death. Calcium uptake occurs through a channel called the uniporter that resides in the inner mitochondrial membrane. Used comparative genomics to identify MICU1 and MCU as the key regulatory and putative pore-forming subunits of this channel, respectively. MICU1 is an essential gatekeeper for MCU-mediated mitochondrial Ca(2+) uptake that regulates cell survival.
Northern blot analysis detected 1.8- and 3.5-kb CBARA1 transcripts in an epithelial cell line but not in endothelial cells. Immunoblot analysis showed reactivity of AD sera but not systemic lupus erythematosus sera with CBARA1.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Calcium Uptake Protein 1, Mitochondrial (MICU1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Calcium Uptake Protein 1, Mitochondrial (MICU1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Calcium Uptake Protein 1, Mitochondrial (MICU1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Calcium Uptake Protein 1, Mitochondrial (MICU1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Calcium Uptake Protein 1, Mitochondrial (MICU1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Calcium Uptake Protein 1, Mitochondrial (MICU1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Calcium Uptake Protein 1, Mitochondrial (MICU1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Calcium Uptake Protein 1, Mitochondrial (MICU1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Calcium Uptake Protein 1, Mitochondrial (MICU1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Calcium Uptake Protein 1, Mitochondrial (MICU1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Calcium Uptake Protein 1, Mitochondrial (MICU1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Calcium Uptake Protein 1, Mitochondrial (MICU1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Calcium Uptake Protein 1, Mitochondrial (MICU1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Calcium Uptake Protein 1, Mitochondrial (MICU1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Calcium Uptake Protein 1, Mitochondrial (MICU1) ELISA Kit Customized Service Offer
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  7. "MICU1 encodes a mitochondrial EF hand protein required for Ca(2+) uptake."Nature 467:291-296(2010) [PubMed] [Europe PMC] [Abstract]
  8. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  9. "Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter."Nature 476:341-345(2011) [PubMed] [Europe PMC] [Abstract]
  10. "MICU1 is an essential gatekeeper for MCU-mediated mitochondrial Ca(2+) uptake that regulates cell survival."Cell 151:630-644(2012) [PubMed] [Europe PMC] [Abstract]
  11. "Mitochondrial Ca2+ uptake 1 (MICU1) and mitochondrial ca2+ uniporter (MCU) contribute to metabolism-secretion coupling in clonal pancreatic beta-cells."J. Biol. Chem. 287:34445-34454(2012) [PubMed] [Europe PMC] [Abstract]
  12. "MCUR1 is an essential component of mitochondrial Ca(2+) uptake that regulates cellular metabolism."Nat. Cell Biol. 14:1336-1343(2012) [PubMed] [Europe PMC] [Abstract]
  13. "MICU1 controls both the threshold and cooperative activation of the mitochondrial Ca(2+) uniporter."Cell Metab. 17:976-987(2013) [PubMed] [Europe PMC] [Abstract]
  14. "MICU1 motifs define mitochondrial calcium uniporter binding and activity."Cell Rep. 5:1576-1588(2013) [PubMed] [Europe PMC] [Abstract]
  15. "EMRE is an essential component of the mitochondrial calcium uniporter complex."Science 342:1379-1382(2013) [PubMed] [Europe PMC] [Abstract]
  16. "Dynamics of mitochondrial Ca2+ uptake in MICU1-knockdown cells."Biochem. J. 458:33-40(2014) [PubMed] [Europe PMC] [Abstract]
  17. "MICU1 and MICU2 play nonredundant roles in the regulation of the mitochondrial calcium uniporter."EMBO Rep. 15:299-307(2014) [PubMed] [Europe PMC] [Abstract]
  18. "MICU1 and MICU2 finely tune the mitochondrial Ca(2+) uniporter by exerting opposite effects on MCU activity."Mol. Cell 53:726-737(2014) [PubMed] [Europe PMC] [Abstract]
  19. "Loss-of-function mutations in MICU1 cause a brain and muscle disorder linked to primary alterations in mitochondrial calcium signaling." Nat. Genet. 46:188-193(2014) [PubMed] [Europe PMC] [Abstract]
  20. "Structural and mechanistic insights into MICU1 regulation of mitochondrial calcium uptake."EMBO J. 33:594-604(2014) [PubMed] [Europe PMC] [Abstract]