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Coiled Coil Alpha Helical Rod Protein 1 (CCHCR1)

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HCR; SBP; Pg8; C6orf18; Alpha-helical coiled-coil rod protein; Putative gene 8 protein

Coiled Coil Alpha Helical Rod Protein 1 (CCHCR1)
CCC J480
HGNC 13930
MGI 2385321
PubMed 23189171
RGD CCHCR1
UniProt Q8TD31
Wiki CCHCR1
The HCR gene encodes a protein of 757 amino acids. RT-PCR analysis showed that HCR was expressed at variable levels in all human tissues tested, more abundantly in heart, liver, skeletal muscle, kidney, and pancreas, and less so in lung and placenta.
In genetically engineered mice, certain CCHCR1 polymorphisms cause upregulation of the expression of KRT6A, KRT16, KRT17 and change in expression in other genes associated with terminal differentiation and formation of the cornified cell envelope. These CCHCR1 polymorphisms may therefore be associated with a susceptibility to psoriasis. Defective functioning of CCHCR1 may lead to abnormal keratinocyte proliferation which is a key feature of psoriasis.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Coiled Coil Alpha Helical Rod Protein 1 (CCHCR1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Coiled Coil Alpha Helical Rod Protein 1 (CCHCR1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Coiled Coil Alpha Helical Rod Protein 1 (CCHCR1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Coiled Coil Alpha Helical Rod Protein 1 (CCHCR1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Coiled Coil Alpha Helical Rod Protein 1 (CCHCR1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Coiled Coil Alpha Helical Rod Protein 1 (CCHCR1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Coiled Coil Alpha Helical Rod Protein 1 (CCHCR1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Coiled Coil Alpha Helical Rod Protein 1 (CCHCR1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Coiled Coil Alpha Helical Rod Protein 1 (CCHCR1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Coiled Coil Alpha Helical Rod Protein 1 (CCHCR1) ELISA Kit Customized Service Offer
  1. "Coding haplotype analysis supports HCR as the putative susceptibility gene for psoriasis at the MHC PSORS1 locus." Hum. Mol. Genet. 11:589-597(2002) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Association analysis using refined microsatellite markers localizes a susceptibility locus for psoriasis vulgaris within a 111kb segment telomeric to the HLA-C gene."Hum. Mol. Genet. 8:2165-2170(1999) [PubMed] [Europe PMC] [Abstract]
  6. "A candidate gene for psoriasis near HLA-C, HCR (Pg8), is highly polymorphic with a disease-associated susceptibility allele."Hum. Mol. Genet. 9:1533-1542(2000) [PubMed] [Europe PMC] [Abstract]
  7. "HCR, a candidate gene for psoriasis, is expressed differently in psoriasis and other hyperproliferative skin disorders and is downregulated by interferon-gamma in keratinocytes."J. Invest. Dermatol. 121:1360-1364(2003) [PubMed] [Europe PMC] [Abstract]
  8. "The HCR gene on 6p21 is unlikely to be a psoriasis susceptibility gene."J. Invest. Dermatol. 116:750-754(2001) [PubMed] [Europe PMC] [Abstract]